Results 61 to 70 of about 7,402 (232)

Coxsackievirus A11 is an immunostimulatory oncolytic virus that induces complete tumor regression in a human non-small cell lung cancer

Scientific Reports, 2023
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Innovative treatment is required to improve overall survival rates for advanced NSCLC.
Akira Sakamoto, Hiroyuki Inoue, Shohei Miyamoto, Shun Ito, Yasushi Soda, Kenzaburo Tani   +5 more
doaj   +1 more source

Oncolytic Virus Infection Modulates Lysine Acetyltransferase in Gliomas: Comprehensive Analysis and Experimental Validation of KAT8 in Glioma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 8, April 2025.
ABSTRACT Oncolytic virotherapy, which uses engineered viruses to selectively target tumour cells, has emerged as a potential treatment in glioma. However, how oncolytic virus infection modulates lactylation enzymes in gliomas remains unclear. The RNA‐seq data after oncolytic virus EV‐A71 infection on glioma cells was analysed to screen and lysine ...
Xiaofeng Yin, Zhen Hao, Qi Liu, Rui Ding, Laizhao Chen, Mingliang Jin, Songquan Wang   +6 more
wiley   +1 more source

Single-cell RNA sequencing reveals a strong connection between Gadd45g upregulation and oncolytic HSV infection in tumor tissue

Molecular Therapy: Oncolytics, 2021
The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang   +3 more
doaj  

Generalized Hamiltonian and Lagrangian aspects of a model for virus–tumor interaction in oncolytic virotherapy

Mathematical Methods in the Applied Sciences, Volume 48, Issue 4, Page 4173-4184, 15 March 2025.
We analyze the generalized Hamiltonian structure of a system of first‐order ordinary differential equations for the Jenner et al. system (Letters in Biomathematics 5 (2018), no. S1, S117–S136). The system of equations is used for modeling the interaction of an oncolytic virus with a tumor cell population.
Partha Guha, Anindya Ghose‐Choudhury
wiley   +1 more source

In vitro and in vivo evaluation of the cyclophosphamide effect along with oncolytic Newcastle disease virus (NDV): An animal preclinical research

Malignancy Spectrum, Volume 2, Issue 1, Page 13-25, March 2025.
This article explores combining Newcastle disease virus (NDV) with chemotherapy for treating breast cancer. Results show promising effects, including tumor suppression and improved patient prognosis without harming healthy tissues. The study suggests that NDV combined with chemotherapy could be a valuable treatment option, highlighting its potential ...
Mohammad Reza Foroughi‐Gilvaee, Alireza Jahandideh, Mohammad Faranoush, Reza Nekouian   +3 more
wiley   +1 more source

Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?

OncoImmunology, 2019
Oncolytic viruses (OVs) preferentially target and kill cancer cells without affecting healthy cells through a multi-modal mechanism of action. While historically the direct killing activity of OVs was considered the primary mode of action, initiation or ...
Maria Eugenia Davola, Karen Louise Mossman   +1 more
doaj   +1 more source

Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses

Veterinary and Comparative Oncology, Volume 23, Issue 1, Page 42-51, March 2025.
ABSTRACT Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low‐grade tumours. As a result, new treatment strategies are being sought.
Yeganeh Mehrani, Julia E. Kakish, Christina Napoleoni, Jennifer Jane Thompson, Jason P. Knapp, Jessica A. Minott, Jacob G. E. Yates, Deirdre Stuart, Brenda L. Coomber, Robert A. Foster, Byram W. Bridle, Khalil Karimi   +11 more
wiley   +1 more source

Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances

Molecular Therapy: Oncolytics, 2019
Oncolytic viruses (OVs) are powerful new therapeutic agents in cancer therapy. With the first OV (talimogene laherparepvec [T-vec]) obtaining US Food and Drug Administration approval, interest in OVs has been boosted greatly.
Meijun Zheng, Jianhan Huang, Aiping Tong, Hui Yang   +3 more
doaj  

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

Nature Communications
Oncolytic virotherapy holds promise for cancer treatment, but the factors determining its oncolytic activity remain unclear. Neutrophil extracellular traps (NETs) are associated with cancer progression, yet their formation mechanism and role in oncolytic
Weiwei Dai, Ruotong Tian, Liubing Yu, Shasha Bian, Yuling Chen, Bowen Yin, Yuxuan Luan, Siqi Chen, Zhuoyang Fan, Rucheng Yan, Xin Pan, Yingyong Hou, Rong Li, Juxiang Chen, Minfeng Shu   +14 more
doaj   +1 more source

Cell cycle‐based antibody selection for suppressing cancer cell growth

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Antibody selection for inducing tumor growth inhibition by in the G0/G1 phase. Cell cycle arrest and programmed cell death are crucial in cancer development, making the regulation of cell fate decisions essential for inducing these processes. We present a novel method using fluorescence‐activated cell sorting (FACS) to select antibodies from a library ...
Chi Hun Song, Chih‐Wei Lin, Kyung Ho Han   +2 more
wiley   +1 more source