Results 71 to 80 of about 28,421 (276)

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

Molecular Cancer, 2020
As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials. Oncolytic viruses have the capacity for conditional-replication within carcinoma cells leading to cell death via
Bin Zhang, Ping Cheng
doaj   +1 more source

Measles virus causes immunogenic cell death in human melanoma [PDF]

, 2011
Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma.
Bond, Jacquelyn, Donnelly, Oliver G, Errington-Mais, Fiona, Hadac, Elizabeth, Harrington, Kevin, Jennings, Victoria, Melcher, Alan A, Pandha, Hardev, Peach, Howard, Phillips, Roger M, Russell, Stephen, Scott, Karen, Selby, Peter, Steele, Lynette, Vile, Richard   +14 more
core   +1 more source

Tumor-Associated Macrophages/Microglia in Glioblastoma Oncolytic Virotherapy: A Double-Edged Sword

International Journal of Molecular Sciences, 2022
Oncolytic virotherapy is a rapidly progressing field that uses oncolytic viruses (OVs) to selectively infect malignant cells and cause an antitumor response through direct oncolysis and stimulation of the immune system.
Sarah E. Blitz, A. Kappel, F. Gessler, Neil V. Klinger, O. Arnaout, Yi Lu, Pierpaolo Peruzzi, Timothy R. Smith, E. Chiocca, G. Friedman, J. Bernstock   +10 more
semanticscholar   +1 more source

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion [PDF]

, 2017
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms ...
Bartolini, Caretti, Cockle, Cockle, Demuth, Dumontet, Etienne-Manneville, Etienne-Manneville, Etienne-Manneville, Fangusaro, Ganguly, Grimes, Hargrave, Harrow, Jones, Kaufman, Khatua, Kirschner, Liao, Louis, Louis, Luo, Lyman, Naghavi, Papanastassiou, Peris, Prestwich, Radtke, Rampling, Reed, Russell, Schroeder, Schulze, Sun, Taylor, Tran, Turnbull, Waterman-Storer, Wollmann   +38 more
core   +3 more sources

The use of oncolytic virotherapy in the neoadjuvant setting

Journal for ImmunoTherapy of Cancer, 2022
Surgical removal of tumors remains a front-line therapy for many types of cancer. However, this treatment often fails to eradicate disease due to either recurrence of the original tumor or development of distant micrometastases.
Raquela J. Thomas, E. Bartee
semanticscholar   +1 more source

Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages

Journal of Translational Medicine, 2023
Oncolytic viruses (OVs) for cancer treatment are in a rapid stage of development, and the direct tumor lysis and activation of a comprehensive host immune response are irreplaceable advantages of cancer immunotherapy.
Zhen Shen, Xiyu Liu, Guixiang Fan, Jintong Na, Qiaoqiao Liu, Faquan Lin, Zhikun Zhang, Liping Zhong   +7 more
doaj   +1 more source

Oncolytic polio virotherapy of cancer [PDF]

Cancer, 2014
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
Michael C, Brown, Elena Y, Dobrikova, Mikhail I, Dobrikov, Ross W, Walton, Sarah L, Gemberling, Smita K, Nair, Annick, Desjardins, John H, Sampson, Henry S, Friedman, Allan H, Friedman, Douglas S, Tyler, Darell D, Bigner, Matthias, Gromeier   +12 more
openaire   +2 more sources

The Role of Neutrophils in Oncolytic Orf Virus-Mediated Cancer Immunotherapy

Cells, 2022
Neutrophils are innate leukocytes with diverse effector functions that allow them to respond to pathogens rapidly. Accumulating evidence has highlighted these cells’ complex roles in the host’s response to viral infections and tumor progression ...
Jessica A. Minott, Jacob P. van Vloten, Lily Chan, Yeganeh Mehrani, Byram W. Bridle, Khalil Karimi   +5 more
doaj   +1 more source

Cytolytic Properties and Genome Analysis of Rigvir® Oncolytic Virotherapy Virus and Other Echovirus 7 Isolates

Viruses, 2022
Rigvir® is a cell-adapted, oncolytic virotherapy enterovirus, which derives from an echovirus 7 (E7) isolate. While it is claimed that Rigvir® causes cytolytic infection in several cancer cell lines, there is little molecular evidence for its oncolytic ...
E. Hietanen, Marika K A Koivu, P. Susi
semanticscholar   +1 more source

Tumor Restrictions to Oncolytic Virus

Biomedicines, 2014
Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models.
Markus Vähä-Koskela, Ari Hinkkanen
doaj   +1 more source