Results 71 to 80 of about 7,402 (232)

Cytokine‐armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells

International Journal of Cancer, Volume 156, Issue 3, Page 638-651, 1 February 2025.
What's New? Pancreatic adenocarcinoma is characterized by a high stroma content and an immunosuppressive tissue environment. Here, the authors investigated the capacity of vaccinia viruses to stimulate the human innate immune system upon exposure to pancreatic carcinoma cells.
Ruonan Wang, Mengwen Hu, Isis Lozzi, Cao Zhong Jing Jin, Dou Ma, Katrin Splith, Jörg Mengwasser, Vincent Wolf, Linda Feldbrügge, Peter Tang, Lea Timmermann, Karl Herbert Hillebrandt, Marieluise Kirchner, Philipp Mertins, Georg Hilfenhaus, Christopher Claudius Maximilian Neumann, Thomas Kammertoens, Johann Pratschke, Thomas Malinka, Igor Maximillian Sauer, Elfriede Noessner, Zong Sheng Guo, Matthäus Felsenstein   +22 more
wiley   +1 more source

Decorin Expressed From Herpes Simplex Virus Vector Improves Oncolytic Efficacy in Lung Adenocarcinoma Cells

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT Decorin (DCN) is a small extracellular proteoglycan with significant oncosuppressive activity. Lung adenocarcinoma is commonly devoid of DCN expression and is a leading cause of cancer mortality globally. As a proof‐of‐concept study for evaluating the oncosuppressive potential of DCN expression in lung adenocarcinoma cells, we constructed an ...
Fanny Frejborg, Jussi Palomäki, Kiira Kalke, Julius Orpana, Oliver Koivisto, Henrik Paavilainen, Jessica M. Rosenholm, Hongbo Zhang, Veijo Hukkanen, Hannu Järveläinen   +9 more
wiley   +1 more source

Oncolytic Viruses Partner With T-Cell Therapy for Solid Tumor Treatment

Frontiers in Immunology, 2018
Adoptive T-cell immunotherapies, including chimeric antigen receptor-modified T-cells (CAR-T cells), have revolutionized cancer treatment, especially for hematologic malignancies.
Amanda Rosewell Shaw, Amanda Rosewell Shaw, Masataka Suzuki, Masataka Suzuki   +3 more
doaj   +1 more source

Oncolytic herpes simplex virus propagates tertiary lymphoid structure formation via CXCL10/CXCR3 to boost antitumor immunity

Cell Proliferation, Volume 58, Issue 1, January 2025.
Schematic diagram illustrating the induction of TLS using oHSV to boost immunotherapy. oHSV induces TLS formation and activate the immune system. oHSV‐mediated TLS formation upregulates CXCL10/CXCR3 pathway to recruit stem‐like CD8+ T cells and enhance immune checkpoint blockade response.
Meng‐Jie Zhang, Wen‐Ping Lin, Qing Wang, Shuo Wang, An Song, Yuan‐Yuan Wang, Hao Li, Zhi‐Jun Sun   +7 more
wiley   +1 more source

Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization.

PLoS Computational Biology, 2019
Oncolytic virotherapies, including the modified herpes simplex virus talimogene laherparepvec (T-VEC), have shown great promise as potent instigators of anti-tumour immune effects.
Tyler Cassidy, Morgan Craig
doaj   +1 more source

Advancements and challenges in brain cancer therapeutics

Exploration, Volume 4, Issue 6, December 2024.
The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi‐modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety.
Fan Bai, Yueyang Deng, Long Li, Ming Lv, Jamoliddin Razzokov, Qingnan Xu, Zhen Xu, Zhaowei Chen, Guojun Chen, Zhitong Chen   +9 more
wiley   +1 more source

Optimal control problems for a parabolic system modeling glioma therapy [PDF]

arXiv, 2022
In this paper we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are ...
arxiv  

Oncolytic viruses as anticancer vaccines

Frontiers in Oncology, 2014
Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well. Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses are now designed as ...
Norman eWoller, Engin eGürlevik, Cristina-Ileana eUreche, Anja eSchumacher, Florian eKühnel   +4 more
doaj   +1 more source

Bioinspired micro‐ and nanostructured systems for cancer therapy

MedComm, Volume 5, Issue 12, December 2024.
Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers have employed bioengineering, bioconjugation, and micro‐ or nanotechnology to fabricate bioinspired micro‐ and nanostructured
Rui Yang, Bing Zhang, Xiawei Fei, Shanshan Cong, Shaojie Zhao, Tao Zhou, Yanting Shen   +6 more
wiley   +1 more source

Analysis and Algorithmic Construction of Self-Assembled DNA Complexes [PDF]

arXiv, 2023
DNA self-assembly is an important tool that has a wide range of applications such as building nanostructures, the transport of target virotherapies, and nano-circuitry. Tools from graph theory can be used to encode the biological process of DNA self-assembly.
arxiv