Results 91 to 100 of about 1,058,979 (232)

Construction of three strains of recombinant oncolytic vaccinia virus and their anti-tumor activity [PDF]

Jichu yixue yu linchuang, 2020
Objective The aim of this study is to construct a recombinant oncolytic vaccinia virus with CCL5 and SSTR2 genes and to detect its antitumor activity. Methods Recombinant vaccinia virus eukaryotic expression plasmid pSC65-CCL5-SSTR2-Luc+ was constructed.
LI Dan-yang, FANG Jing-jing, TANG Hui
doaj  

Neutrophils in oncolytic virus immunotherapy

Frontiers in Immunology
Oncolytic viruses have emerged as a highly promising modality for cancer treatment due to their ability to replicate specifically within tumors, carry therapeutic genes, and modulate the immunosuppressive tumor microenvironment through various mechanisms. Additionally, they show potential synergy with immune checkpoint inhibitors.
Danya Zhou, Danya Zhou, Chenglin Zhang, Jingyi Sun, Ming Yuan   +4 more
openaire   +3 more sources

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity

, 2022
Summary: The emergence of cellular resistances to oncolytic viruses is an underexplored process that could compromise the efficacy of cancer virotherapy. Here, we isolated and characterized B16 mouse melanoma cells that evolved resistance to an oncolytic
Rafael Sanjuán, Larrieux, Alejandra, Alejandra Larrieux, Sanjuán, Rafael   +3 more
core   +1 more source

Intravenous Injections of a Rationally Selected Oncolytic Herpes Virus as a Potent Virotherapy for Hepatocellular Carcinoma

Molecular Therapy: Oncolytics, 2019
As a clinical setting in which novel treatment options are urgently needed, hepatocellular carcinoma (HCC) exhibits intriguing opportunities for oncolytic virotherapy.
Yong Luo, Chaolong Lin, Wenfeng Ren, Fei Ju, Zilong Xu, Huiling Liu, Zeng Yu, Jun Chen, Jun Zhang, Pingguo Liu, Chenghao Huang, Ningshao Xia   +11 more
doaj   +1 more source

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, EarlyView.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

Oral Diseases, EarlyView.
ABSTRACT Objective Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin‐12 (IL‐12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. Methods The effects
Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi   +11 more
wiley   +1 more source

Oncolytic Virus Animal Model

, 2023
 To fully optimize oncolytic virotherapy and provide meaningful mechanistic insight, it is critical to have animal models for oncolytic virus study in various tumor types. 
candy swift (14858320)
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker [PDF]

, 2010
The oncolytic adenovirus dl922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers.
Balkwill, F.R., Magdalena B Flak, Balkwill, FR, Chelala, C, McNeish, IA, Archibald, Kyra, Pirlo, K.J., Chelala, C., Iain A McNeish, Flak, M.B., Salako, MA, Pirlo, KJ, Katrina J Pirlo, Salako, M.A., Lockley, M, Connell, C.M., Mcneish, I.A., Lockley, M., Wheatley, S.P., Wheatley, SP, Flak, Magdalena B; id_orcid, Archibald, K, Archibald, K., Flak, MB, Michael A Salako, Michelle Lockley, Claude Chelala, McNeish, Iain A, Kyra Archibald, Frances R Balkwill, Pirlo, Katrina J, Lockley, Michelle, Connell, CM, Sally P Wheatley, Chelala, Claude, Balkwill, Frances R, Connell, Claire M, Claire M Connell, Salako, Michael A, Wheatley, Sally P   +39 more
core   +1 more source