Results 201 to 210 of about 21,338 (215)

Measles as a potential oncolytic virus

Reviews in Medical Virology, 2005
The use of replicating viruses for cancer therapy is attracting increasing interest. Numerous viruses are now being considered as potential cancer therapeutics, including the vaccine strain of measles virus (MV). The attenuated strain of measles readily lyses transformed cells, whilst replication and lysis are limited in normal human cells.
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Oncolytic virus preclinical toxicology studies

Journal of Applied Toxicology, 2022
AbstractWith the ever‐emerging concerns of patient safety during medical care, the search for treatments as safe as possible is a priority, especially when focusing on cancer treatment of which therapies often go hand in hand with severe side effects.
Agnija Rasa, Pēteris Alberts
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Regulatory Aspects of Oncolytic Virus Products

Current Cancer Drug Targets, 2007
Many types of oncolytic viruses, wild-type virus, attenuated viruses and genetically-modified viruses, have been developed as an innovative cancer therapy. The strategies, nature, and technologies of oncolytic virus products are different from the conventional gene therapy products or cancer therapy products.
Teruhide Yamaguchi, Eriko Uchida
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Oncolytic vaccinia virus for the treatment of cancer

Expert Opinion on Biological Therapy, 2011
Gene therapy offers promising approaches for the development of anticancer agents with new modes of action. Among gene therapy vectors, vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus.This review describes the use of vaccinia virus in cancer therapy as a gene therapy vector, as an oncolytic virus and in the ...
Akseli Hemminki, Kilian Guse, Vincenzo Cerullo   +2 more
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Cancer gene and oncolytic virus therapy

Seminars in Oncology, 2001
By far, cancer accounts for the majority of gene therapy trials that are being carried out worldwide. Seventy percent of the gene therapy protocols that have been reviewed by the National Institutes of Health Recombinant DNA Advisory Committee (NIH RAC) are for the treatment of cancer.
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Oncolytic virus therapy for prostate cancer

International Journal of Urology, 2009
AbstractThe use of replication‐competent viruses that can selectively replicate in and destroy neoplastic cells is an attractive strategy for treating cancer. Various oncolytic viruses have been taken to clinical trials since a recombinant virus was first applied to cancer patients a decade ago.
Yukio Homma, Hiroshi Fukuhara, Tomoki Todo   +2 more
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Measles Virus as An Oncolytic Vector Platform

Current Gene Therapy, 2008
Viral vector systems are widely being used in the development of new genetic approaches for a variety of human diseases. Oncolytic viruses have shown great potential as cancer therapeutics. The ideal viral vector for cancer gene therapy eradicates a clinically significant fraction of malignant cells and leaves normal tissues unharmed.
Stephen J. Russell, Boris Blechacz
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Modification of HSV-1 to an Oncolytic Virus

2014
Cancer-permissive viruses or oncolytic viruses consist of either genetically engineered or naturally occurring strains that possess relatively selective replicative and/or infection abilities for cancer vs. normal cells (Chiocca, Nat Rev Cancer 2: 938-950, 2002).
Hiroshi Nakashima, E. Antonio Chiocca
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Oncolytic Virus Immunotherapy in Sarcoma

2018
Oncolytic viruses (OVs) are tumor-specific, live agents that actively replicate and function to kill cancer and associated stromal cells through a dual mechanism—a direct, cytotoxic effect and an indirect immune-mediated response. Because OVs are live viral particles, recombinant technologies are used to engineer safe and effective viruses that have a ...
Mohammed M. Milhem, Varun Monga, Seth M. Maliske   +2 more
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Vesicular Stomatitis Virus as an Oncolytic Vector

Viral Immunology, 2004
Recent data has shown that viruses such as vesicular stomatitis virus (VSV), a relatively non-pathogenic, negative-stranded RNA virus, can preferentially replicate in malignant cells and less so in normal cells. VSV appears able to carry out this function in transformed cells since these hosts exhibit the hallmarks of flawed host defense, probably ...
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