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Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M. [PDF]
Cancers (Basel)Yoshimura T +12 more
europepmc +1 more source
Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway. [PDF]
J Orthop Surg ResYang J, Chen X, Wu Y, Xu G, Qu X.
europepmc +1 more source
Oncostatin M: A mysterious cytokine in cancers
International Immunopharmacology, 2021 Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor
Ali, Masjedi +7 more
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Upregulation of Oncostatin M in Allergic Rhinitis
Laryngoscope, 2005AbstractObjectives: Oncostatin M is a multifunctional cytokine belonging to the interleukinâ6 family of cytokines. It has been implicated as an important modulator of lower airway remodeling in the setting of asthma. However, there have been few studies regarding a similar role for the upper airway epithelium in the setting of allergic rhinitis.
Hee Joon Kang +2 more
exaly +3 more sources
Regulation of Cell Growth by Recombinant Oncostatin M
Growth Factors, 1990Oncostatin M is a novel growth regulator originally isolated from differentiated human histiocytic lymphoma cells and activated T-lymphocytes based on its ability to inhibit the growth of A375 melanoma cells. We report here that oncostatin M is a widely acting regulator which alters the growth and/or morphology of cells derived from a variety of cancer
Diane Horn, G J Todaro, Peter S Linsley
exaly +3 more sources
Cytokine, 1994
Oncostatin M was found to stimulate the IL-6-addicted hybridoma line B9. Leukaemia inhibitory factor did not stimulate proliferation of this line. Both of these factors bind to the gp130 of the IL-6 receptor. In another cell line that is stimulated by LIF (DA.1), neither IL-6 nor oncostatin M stimulated proliferation.
B E, Barton +3 more
exaly +3 more sources
Oncostatin M was found to stimulate the IL-6-addicted hybridoma line B9. Leukaemia inhibitory factor did not stimulate proliferation of this line. Both of these factors bind to the gp130 of the IL-6 receptor. In another cell line that is stimulated by LIF (DA.1), neither IL-6 nor oncostatin M stimulated proliferation.
B E, Barton +3 more
exaly +3 more sources
Progress in Growth Factor Research, 1992
Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony ...
A G, Bruce, P S, Linsley, T M, Rose
openaire +2 more sources
Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony ...
A G, Bruce, P S, Linsley, T M, Rose
openaire +2 more sources
Crystal structure and functional dissection of the cytostatic cytokine oncostatin M
Structure, 2000 BACKGROUND: The cytokine oncostatin M (OSM) inhibits growth of certain tumour-derived cells, induces proliferation in other cell types (e.g. haemangioblasts) and is a mediator of inflammatory responses.
Marc C Deller +2 more
exaly +2 more sources
Atherosclerosis, 2011
Chronic inflammation plays a pivotal role in the development and progression of atherosclerosis. The inflammatory response is mediated by cytokines. The aim of this study was to determine if Oncostatin M (OSM), a monocyte and T-lymphocyte specific cytokine is present in atherosclerotic lesions.
Albasanz-Puig, Adaia +8 more
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Chronic inflammation plays a pivotal role in the development and progression of atherosclerosis. The inflammatory response is mediated by cytokines. The aim of this study was to determine if Oncostatin M (OSM), a monocyte and T-lymphocyte specific cytokine is present in atherosclerotic lesions.
Albasanz-Puig, Adaia +8 more
openaire +3 more sources