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Oncostatin M: Development of a Pleiotropic Cytokine
Toxicologic Pathology, 1999Oncostatin M (OM) is a member of the interleukin-6 (IL-6) cytokine subfamily. The binding of OM to its receptor initiates signal transduction through JAK-signal transducers and activators of transcription (STAT) pathways and activates transcription activators through mitogen-activated protein (MAP) kinases. Results of in vitro assays documented that OM
J K, Loy +5 more
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Regulation of Inflammatory Responses by Oncostatin M
The Journal of Immunology, 1999Abstract Oncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares properties with related proteins of the IL-6 family of cytokines; however, its in vivo properties and physiological function are as yet ill defined.
P M, Wallace +6 more
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Oncostatin M in the anti-inflammatory response
Annals of the Rheumatic Diseases, 2001Oncostatin M (OM) is a pleiotropic cytokine of the interleukin 6 family, whose in vivo properties and physiological function remain in dispute and poorly defined. These in vivo studies strongly suggest that OM is anabolic, promoting wound healing and bone formation, and anti-inflammatory.
A F, Wahl, P M, Wallace
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1995
Abstract OSM is a secreted glycoprotein monomer with a M, of 28 000 Da (Zarling et al. 1986). Nucleotide sequence analysis of OSM cDNA and genomic clones (human sequence-GenBank accession numbers M27286, M27287, M27288, M26966; Simian sequence-unpublished), determined that OSM was initially expressed as a 252-amino-acid precursor ...
T M Rose, A G Bruce
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Abstract OSM is a secreted glycoprotein monomer with a M, of 28 000 Da (Zarling et al. 1986). Nucleotide sequence analysis of OSM cDNA and genomic clones (human sequence-GenBank accession numbers M27286, M27287, M27288, M26966; Simian sequence-unpublished), determined that OSM was initially expressed as a 252-amino-acid precursor ...
T M Rose, A G Bruce
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Oncostatin M as a target biological molecule of preeclampsia
Journal of Obstetrics and Gynaecology Research, 2009AbstractAim: Given the presence of the cytokinetic effects of Oncostatin M (OSM), we hypothesized that placental expression of OSM and serum OSM levels are elevated in preeclampsia. To verify this hypothesis, we determined the expression of OSM in placenta and levels of OSM in plasma form women with preeclampsia and normal pregnant women.Methods ...
Guisera, Lee +5 more
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Role of Oncostatin M in hematopoiesis and liver development
Cytokine & Growth Factor Reviews, 2000Definitive hematopoietic stem cells (HSCs) first appear in the aorta/gonad/mesonephros (AGM) region and migrate to the fetal liver where they massively produce hematopoietic cells before establishing hematopoiesis in the bone marrow at a perinatal stage.
A, Miyajima +5 more
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Oncostatin M in the development of the nervous system
Anatomical Science International, 2005Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines. Of these cytokines, OSM is closely related structually, genetically and functionally to leukemia inhibitory factor. However, OSM-specific biological activities have been reported in hematopoiesis and liver development.
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Oncostatin M: Signal transduction and biological activity
Life Sciences, 1999Oncostatin M (OSM) is a multifunctional cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family. OSM shares properties with all members of this family of cytokines, but is most closely related structurally and functionally to LIE OSM ...
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