Results 171 to 180 of about 19,011 (195)
Blocking Oncostatin M receptor abrogates STAT3 mediated integrin signaling and overcomes chemoresistance in ovarian cancer. [PDF]
NPJ Precis OncolGeethadevi A +13 more
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Progress in Growth Factor Research, 1992
Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony ...
A G, Bruce, P S, Linsley, T M, Rose
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Oncostatin M (OSM) was initially identified as a polypeptide cytokine which inhibited the in vitro growth of cells from melanoma and other solid tumors. OSM shows significant similarities in primary amino acid sequence and predicted secondary structure to leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), granulocyte colony ...
A G, Bruce, P S, Linsley, T M, Rose
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Oncostatin M: A mysterious cytokine in cancers
International Immunopharmacology, 2021Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Overexpression of OSM and OSM receptor
Ali, Masjedi +7 more
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1995
Abstract OSM is a secreted glycoprotein monomer with a M, of 28 000 Da (Zarling et al. 1986). Nucleotide sequence analysis of OSM cDNA and genomic clones (human sequence-GenBank accession numbers M27286, M27287, M27288, M26966; Simian sequence-unpublished), determined that OSM was initially expressed as a 252-amino-acid precursor ...
T M Rose, A G Bruce
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Abstract OSM is a secreted glycoprotein monomer with a M, of 28 000 Da (Zarling et al. 1986). Nucleotide sequence analysis of OSM cDNA and genomic clones (human sequence-GenBank accession numbers M27286, M27287, M27288, M26966; Simian sequence-unpublished), determined that OSM was initially expressed as a 252-amino-acid precursor ...
T M Rose, A G Bruce
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Regulation of Inflammatory Responses by Oncostatin M
The Journal of Immunology, 1999AbstractOncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares properties with related proteins of the IL-6 family of cytokines; however, its in vivo properties and physiological function are as yet ill defined.
P M, Wallace +6 more
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Cytokine, 1994
Oncostatin M was found to stimulate the IL-6-addicted hybridoma line B9. Leukaemia inhibitory factor did not stimulate proliferation of this line. Both of these factors bind to the gp130 of the IL-6 receptor. In another cell line that is stimulated by LIF (DA.1), neither IL-6 nor oncostatin M stimulated proliferation.
B E, Barton +3 more
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Oncostatin M was found to stimulate the IL-6-addicted hybridoma line B9. Leukaemia inhibitory factor did not stimulate proliferation of this line. Both of these factors bind to the gp130 of the IL-6 receptor. In another cell line that is stimulated by LIF (DA.1), neither IL-6 nor oncostatin M stimulated proliferation.
B E, Barton +3 more
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Upregulation of Oncostatin M in Allergic Rhinitis
The Laryngoscope, 2005AbstractObjectives: Oncostatin M is a multifunctional cytokine belonging to the interleukinâ6 family of cytokines. It has been implicated as an important modulator of lower airway remodeling in the setting of asthma. However, there have been few studies regarding a similar role for the upper airway epithelium in the setting of allergic rhinitis.
Hee Joon, Kang +6 more
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Oncostatin M in the anti-inflammatory response
Annals of the Rheumatic Diseases, 2001Oncostatin M (OM) is a pleiotropic cytokine of the interleukin 6 family, whose in vivo properties and physiological function remain in dispute and poorly defined. These in vivo studies strongly suggest that OM is anabolic, promoting wound healing and bone formation, and anti-inflammatory.
A F, Wahl, P M, Wallace
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Oncostatin M: Signal transduction and biological activity
Life Sciences, 1999Oncostatin M (OSM) is a multifunctional cytokine produced by activated T lymphocytes and monocytes that is structurally and functionally related to the subfamily of cytokines known as the IL-6-type cytokine family. OSM shares properties with all members of this family of cytokines, but is most closely related structurally and functionally to LIE OSM ...
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Atherosclerosis, 2011
Chronic inflammation plays a pivotal role in the development and progression of atherosclerosis. The inflammatory response is mediated by cytokines. The aim of this study was to determine if Oncostatin M (OSM), a monocyte and T-lymphocyte specific cytokine is present in atherosclerotic lesions.
Albasanz-Puig, Adaia +8 more
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Chronic inflammation plays a pivotal role in the development and progression of atherosclerosis. The inflammatory response is mediated by cytokines. The aim of this study was to determine if Oncostatin M (OSM), a monocyte and T-lymphocyte specific cytokine is present in atherosclerotic lesions.
Albasanz-Puig, Adaia +8 more
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