Results 31 to 40 of about 19,011 (195)
The potential for dietary factors to prevent or treat osteoarthritis [PDF]
, 2014 Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping +8 more
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Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes. [PDF]
, 2020 Inorganic arsenic oxides have been identified as carcinogens in several human tissues, including epidermis. Due to the chemical similarity between trivalent inorganic arsenic (arsenite) and antimony (antimonite), we hypothesized that common intracellular
Cánovas, Angela +7 more
core
Oncostatin M Binds to Extracellular Matrix in a Bioactive Conformation: Implications for Inflammation and Metastasis [PDF]
, 2015 Oncostatin M (OSM) is an interleukin-6-like inflammatory cytokine reported to play a role in a number of pathological processes including cancer. Full-length OSM is expressed as a 26 kDa protein that can be proteolytically processed into 24 kDa and 22 ...
Jacob, Reed B. +7 more
core +2 more sources
Journal of Lipid Research, 1991 Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2).
RI Grove +8 more
doaj +1 more source
Nature Communications, 2021 Cancer-associated fibroblasts (CAFs) are a major component of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDA). Here the authors report the importance of macrophage-derived Oncostatin M in reprogramming CAFs to drive a pro-tumorigenic ...
Brian Y. Lee +14 more
doaj +1 more source
Oncostatin M Promotes Mammary Tumor Metastasis to Bone and Osteolytic Bone Degradation [PDF]
, 2012 Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine that has been implicated in a number of biological processes including inflammation, hematopoiesis, immune responses, development, and bone homeostasis.
Anderson, Robin +7 more
core +2 more sources
Journal of Inflammation Research, 2021 Petra Henning,1 Sofia Movérare-Skrtic,1 Anna Westerlund,1 Pedro Paulo Chaves de Souza,2,3 Thais Floriano-Marcelino,3 Karin H Nilsson,1 Maha El Shahawy,1,4 Claes Ohlsson,1 Ulf H Lerner1 1Department of Internal Medicine and Clinical Nutrition, Institute of
Henning P +8 more
doaj
Acta Dermato-Venereologica, 2020 To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards +4 more
doaj +1 more source
A receptor fusion protein for the inhibition of murine oncostatin M [PDF]
, 2011 Background Most cytokines signal through heteromeric receptor complexes consisting of two or more different receptor subunits. Fusion proteins of the extracellular parts of receptor subunits turned out to be promising cytokine inhibitors ...
Liv Brolund +4 more
core +2 more sources
Human intervention study to assess the effects of supplementation with olive leaf extract on peripheral blood mononuclear cell gene expression [PDF]
, 2016 Olive leaf extract (OLE) has been used for many years for its putative health benefits, but, to date, scientific evidence for the basis of these effects has been weak.
Barnett, Matthew +5 more
core +5 more sources