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Targeting one‐carbon metabolism for cancer immunotherapy [PDF]
Clinical and Translational MedicineBackground One‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to fuel metabolic pathways, including nucleotide metabolism, amino acid metabolism, cellular
Xinxin Ren +9 more
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One‐carbon metabolism, folate, zinc and translation [PDF]
Microbial Biotechnology, 2020 Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental
Antoine Danchin +2 more
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Progress in One-carbon Metabolism and Tumor Therapy
Zhongliu Fangzhi Yanjiu, 2021 In recent years, it has already run into a common view that "tumor is a metabolic disease", and the reprogramming of tumor metabolism has become the focus of current research.
CHAI Dongqi, WANG Weixing
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Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer
Discover Oncology, 2021 Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups.
Carlo Ganini +14 more
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One-carbon metabolism in cancer [PDF]
British Journal of Cancer, 2017 Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells
Newman, Alice C., Maddocks, Oliver D.K.
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COVID-19 and One-Carbon Metabolism
International Journal of Molecular Sciences, 2022 Dysregulation of one-carbon metabolism affects a wide range of biological processes and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Accumulating evidence suggests that one-carbon metabolism plays an important role in COVID-19.
Joanna Perła-Kaján +1 more
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One carbon metabolism in SAR11 pelagic marine bacteria. [PDF]
PLoS ONE, 2011 The SAR11 Alphaproteobacteria are the most abundant heterotrophs in the oceans and are believed to play a major role in mineralizing marine dissolved organic carbon.
Jing Sun +7 more
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The toxic side of one-carbon metabolism and epigenetics
Redox Biology, 2021 One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks.
Agustín E. Morellato +2 more
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One-carbon metabolism and depression [PDF]
British Journal of Psychiatry, 2008 Kim et al concluded that lower levels of folate and vitamin B12 and raised homocysteine may be risk factors for late-life depression.[1][1] We propose to include polyunsaturated fatty acids (PUFAs) in future studies that will test the potential role of one-carbon metabolism in the aetiology ...
Assles, J., Pouwer, F.
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Modeling cellular compartmentation in one‐carbon metabolism [PDF]
WIREs Systems Biology and Medicine, 2013 AbstractFolate‐mediated one‐carbon metabolism (FOCM) is associated with risk for numerous pathological states including birth defects, cancers, and chronic diseases. Although the enzymes that constitute the biological pathways have been well described and their interdependency through the shared use of folate cofactors appreciated, the biological ...
Scotti M. +3 more
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