Results 11 to 20 of about 341,624 (160)

Subcellular one carbon metabolism in cancer, aging and epigenetics [PDF]

Frontiers in Epigenetics and Epigenomics
The crosstalk between metabolism and epigenetics is an emerging field that is gaining importance in different areas such as cancer and aging, where changes in metabolism significantly impacts the cellular epigenome, in turn dictating changes in chromatin
Tiziano Bernasocchi, Tiziano Bernasocchi, Raul Mostoslavsky, Raul Mostoslavsky   +3 more
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392 Targeting One-Carbon Metabolism in Brain Cancer [PDF]

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis.
Emma Rowland, Nagi G. Ayad
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Regulatory mechanisms of one-carbon metabolism enzymes [PDF]

Journal of Biological Chemistry, 2023
One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the transfer of a carbon unit from the amino acid serine, through the cofactor folate (in its several forms), and to the ultimate carbon acceptors that include nucleotides and ...
Boryana Petrova, Adam G. Maynard, Peng Wang, Naama Kanarek   +3 more
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One-carbon metabolism and risk of PCOS: insights from Mendelian randomization [PDF]

Journal of Ovarian Research
Background Abnormal one-carbon metabolism has been reported by observational studies to contribute to an increased risk of polycystic ovary syndrome (PCOS) and undesirable reproductive outcomes in women with PCOS.
Yifan Zhao, Gaochen Zhang, Jiexue Pan, Hefeng Huang   +3 more
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Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease [PDF]

International Journal of Molecular Sciences
Mitochondrial one-carbon metabolism provides carbon units to several pathways, including nucleic acid synthesis, mitochondrial metabolism, amino acid metabolism, and methylation reactions. Late-onset Alzheimer’s disease is the most common age-related neurodegenerative disease, characterised by impaired energy metabolism, and is potentially linked to ...
Yizhou Yu, L. Miguel Martins
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One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Biomolecules, 2022
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory   +3 more
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Interactions between Radiation and One-Carbon Metabolism [PDF]

International Journal of Molecular Sciences, 2022
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism.
Korimerla, Navyateja, Wahl, Daniel R.
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One-carbon and energy metabolism in major depression compared to chronic depression in adolescent outpatients: A metabolomic pilot study

Journal of Affective Disorders Reports, 2021
Background: While considered less severe than major depressive disorder (MDD), chronic depression has a devastating effect on people's lives. Metabolic alterations related to chronicity are still widely unknown.
Karoliina Kurkinen, Olli Kärkkäinen, Soili M. Lehto, Ilona Luoma, Siiri-Liisi Kraav, Anni I. Nieminen, Petri Kivimäki, Sebastian Therman, Tommi Tolmunen   +8 more
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One carbon metabolism in human lung cancer [PDF]

Translational Lung Cancer Research, 2021
Lung cancer remains the major cause of cancer related death worldwide. The discovery of targeted therapies against activating mutations in genes like EGFR considerably improved the prognosis for a subgroup of patients but still leaves a large part without a targeted therapy.
Yao, Sha, Peng, Luogen, Elakad, Omar, Küffer, Stefan, Hinterthaner, Marc, Danner, Bernhard C., Hammerstein-Equord, Alexander von, Ströbel, Philipp, Bohnenberger, Hanibal   +8 more
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One-carbon metabolism during the menstrual cycle and pregnancy.

PLoS Computational Biology, 2021
Many enzymes in one-carbon metabolism (OCM) are up- or down-regulated by the sex hormones which vary diurnally and throughout the menstrual cycle. During pregnancy, estradiol and progesterone levels increase tremendously to modulate physiological changes
Ruby Kim, H Frederik Nijhout, Michael C Reed   +2 more
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