Results 41 to 50 of about 3,584 (213)

Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny

CPT: Pharmacometrics & Systems Pharmacology
Pediatric physiologically‐based modeling in drug development has grown in the past decade and optimizing the underlying systems parameters is important in relation to overall performance.
Trevor N. Johnson, Hannah K. Batchelor, Jan Goelen, Richard D. Horniblow, Jean Dinh   +4 more
doaj   +1 more source

Ontogeny of respiration and feeding structures of skull in Persian sturgeon, Acipenser persicus (Bordin, 1897) [PDF]

بوم‌شناسی آبزیان, 2016
In the present study, the process of the skull development and calcification in Persian sturgeon (Acipenser persicus) was studied. Development of cartilage started after hatching around the head and notochord (10.6 mm, total length, TL) and the first ...
Hamid Eshaghzadeh, Arash Akbarzadeh, Mahtab Yarmohammadi, Enric Gisbert   +3 more
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Intraspecific differences in metabolic rates shape carbon stable isotope trophic discrimination factors of muscle tissue in the common teleost Eurasian perch (Perca fluviatilis)

Ecology and Evolution, 2021
Stable isotopes represent a unique approach to provide insights into the ecology of organisms. δ13C and δ15N have specifically been used to obtain information on the trophic ecology and food‐web interactions. Trophic discrimination factors (TDF, Δ13C and
Kristin Scharnweber, Matilda L. Andersson, Fernando Chaguaceda, Peter Eklöv   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dendritic Cells—Ontogeny—

Allergology International, 2007
Dendritic cells (DC) play key rolls in various aspects of immunity. The functions of DC depend on the subsets as well as their location or activation status. Understanding developmental lineages, precursors and inducing factors for various DC subsets would help their clinical application, but despite extensive efforts, the precise ontogeny of various ...
Satoshi Takeuchi, Masutaka Furue
openaire   +3 more sources

The Enigmatic Schizoglyphid Mite Oriboglyphus maorianus gen. and sp. n. and Its Implications for Astigmatid Life Cycle Evolution

Life
A detailed morphological characterization is presented for Oriboglyphus maorianus gen. et sp. nov., a newly discovered modern representative of the relict family Schizoglyphidae, found in a nest of the termite Stolotermes ruficeps in New Zealand. This is
Pavel B. Klimov, Vasiliy B. Kolesnikov, Matt Shaw, Qing-Hai Fan, Zhi-Qiang Zhang, Barry OConnor   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

New record and ontogenic development of Oligonychus washingtoniae (Trombidiformes: Tetranychidae) based on materials from Iran

Persian Journal of Acarology
Oligonychus washingtoniae Mushtaq, Kamran & Alatawi, 2022 (Acari: Tetranychidae) is reported for the second time in the world based on new materials from Iran. The ontogenetic changes in leg chaetotaxy and new data of this species is also provided.
Sayed Mosayeb Mahdavi, Sara Zarghami, Mahdieh Asadi, Nastaran Rezaei   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source