Results 131 to 140 of about 1,266,792 (389)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Implicit and Explicit Examples of the Phenomenon of Deviant Encodings

Studies in Logic, Grammar and Rhetoric, 2020
The core of the problem discussed in this paper is the following: the Church-Turing Thesis states that Turing Machines formally explicate the intuitive concept of computability. The description of Turing Machines requires description of the notation used
Quinon Paula
doaj   +1 more source

An Approach to Cope with Ontology Changes for Ontology-based Applications

, 2006
Keeping track of ontology changes is becoming a critical issue for ontology-based applications because updating an ontology that is in use may result in inconsistencies between the ontology and the knowledge base, dependent ontologies and dependent ...
Alani, Harith, Dupplaw, David, Liang, Yaozhong, Shadbolt, Nigel   +3 more
core  

The Ontology for Biomedical Investigations

PLoS ONE, 2016
The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted.
A. Bandrowski, R. Brinkman, M. Brochhausen, Matthew H. Brush, B. Bug, M. Chibucos, Kevin Clancy, Mélanie Courtot, Dirk Derom, M. Dumontier, Liju Fan, J. Fostel, G. Fragoso, F. Gibson, Alejandra N. González-Beltrán, M. Haendel, Y. He, M. Heiskanen, T. Hernandez-Boussard, Mark Jensen, Yu Lin, Allyson L. Lister, P. Lord, J. Malone, E. Manduchi, M. McGee, N. Morrison, James A. Overton, H. Parkinson, Bjoern Peters, P. Rocca-Serra, A. Ruttenberg, Susanna-Assunta Sansone, R. Scheuermann, Daniel Schober, Barry Smith, L. Soldatova, C. Stoeckert, Chris F. Taylor, C. Torniai, J. Turner, R. Vita, P. Whetzel, Jie Zheng   +43 more
semanticscholar   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

The bilocated mind: New perspectives on self-localization and self-identification

Frontiers in Human Neuroscience, 2013
Does the human mind allow for self-locating at more than one place at a time? Evidence from neurology, cognitive neuroscience, and experimental psychology suggests that mental bilocation is a complex, but genuine experience, occurring more frequently ...
Tiziano eFurlanetto, Cesare eBertone, Cristina eBecchio   +2 more
doaj   +1 more source

Application of an ontology for model cards to generate computable artifacts for linking machine learning information from biomedical research [PDF]

, 2023
Muhammad Amith, Licong Cui, Kirk Roberts, Cui Tao   +3 more
openalex   +1 more source

Representation Phase: Ontology Usage Ontology (U Ontology)

, 2018
The huge increase in the use of ontologies and Semantic Web data has increased the need for usage-related information to assist stakeholders (or users) to make effective use of currently available semantic information. As noted in earlier chapters, stakeholders can be different groups of users such as ontology developers, domain experts, application ...
Ashraf, J, Hussain, OK, Hussain, FK, Chang, EJ   +3 more
openaire   +2 more sources

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source