Results 41 to 50 of about 917,318 (346)
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Contextualizing ontologies [PDF]
Journal of Web Semantics, 2004 Ontologies are shared models of a domain that encode a view which is common to a set of different parties. Contexts are local models that encode a party's subjective view of a domain. In this paper, we show how ontologies can be contextualized, thus acquiring certain useful properties that a pure shared approach cannot provide.
Bouquet, Paolo +4 more
openaire +4 more sources
How do Ontology Mappings Change in the Life Sciences? [PDF]
, 2012 Mappings between related ontologies are increasingly used to support data integration and analysis tasks. Changes in the ontologies also require the adaptation of ontology mappings.
Gross, Anika +3 more
core
, 2000 Trope ontology is exposed and confronted with the question where one trope ends and another begins. It is argued that tropes do not have determinate boundaries, it is arbitrary how tropes are carved up.
Faye, J. +3 more
core +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Querying clinical data in HL7 RIM based relational model with morph-RDB
Journal of Biomedical Semantics, 2017 Background Semantic interoperability is essential when carrying out post-genomic clinical trials where several institutions collaborate, since researchers and developers need to have an integrated view and access to heterogeneous data sources.
Freddy Priyatna +3 more
doaj +1 more source
An ontological analysis of some biological ontologies [PDF]
Frontiers in Genetics, 2012 The functional importance of biological entities makes their understanding, analysis, and representation essential in modern biology. Arguably, semantic representation necessary for machine interoperability is a far more difficult task than syntactic representation, necessitating conceptual schema and ontologies for in-silico biological knowledge ...
openaire +4 more sources
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
A framework for developing engineering design ontologies within the aerospace industry [PDF]
, 2014 This paper presents a framework for developing engineering design ontologies within the aerospace industry. The aim of this approach is to strengthen the modularity and reuse of engineering design ontologies to support knowledge management initiatives ...
Sanya, I. O., Shehab, Essam
core +1 more source