Results 111 to 120 of about 38,633 (261)
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Advanced Science, EarlyView.Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang +8 more
wiley +1 more source
Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Advanced Science, EarlyView.Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source
An effective method of large scale ontology matching. [PDF]
J Biomed Semantics, 2014 Diallo G.
europepmc +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Advanced Science, EarlyView.TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
Extending structural subsumption reasoning algorithms for ontology matching
Tongxin xuebao, 2012 For exploiting semantics implied in constructors and axioms in an ontology,a structural subsumption reasoning algorithm was extended to match ontologies.The implied semantics was first enabled to be read-off easily by rephrasing entities in an ontology ...
Jian-xin LIAO +4 more
doaj +2 more sources
METHODS, APPROACHES, PRINCIPLES, GUIDELINES AND APPLICATIONS ON MULTILINGUAL ONTOLOGIES: A SURVEY
ICTACT Journal on Soft Computing, 2016 Ontologies are used in various domains to provide meaningful knowledge from data. The data can be in different natural languages. Ontologies with a lexical layer in different natural languages are needed essential to access the multilingual data by the ...
Ravi Lourdusamy, Joseph Merlin Florrence
doaj
, 2004 Ontologies are nowadays used in many domains such as Semantic Web, information systems… to represent meaning of data and data sources. In the framework of knowledge management in an heterogeneous organization, the materialization of the organizational memory in a " corporate semantic web " may require to integrate the various ontologies of the ...
Bach Thanh, Lê +2 more
openaire +1 more source