Results 141 to 150 of about 1,139,414 (359)

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser   +11 more
wiley   +1 more source

Uncertainty in Automated Ontology Matching: Lessons from an Empirical Evaluation

open access: yesApplied Sciences
Data integration is considered a classic research field and a pressing need within the information science community. Ontologies play a critical role in such processes by providing well-consolidated support to link and semantically integrate datasets via
Inès Osman   +2 more
doaj   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

open access: yesAdvanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao   +7 more
wiley   +1 more source

Evaluating Ontology Matching Systems on Large, Multilingual and Real-world Test Cases [PDF]

open access: yes
In the field of ontology matching, the most systematic evaluation of matching systems is established by the Ontology Alignment Evaluation Initiative (OAEI), which is an annual campaign for evaluating ontology matching systems organized by different ...
Aguirre, J-L.   +6 more
core  

Investigating the use of background knowledge for assessing the relevance of statements to an ontology in ontology evolution [PDF]

open access: yes, 2009
The tasks of learning and enriching ontologies with new concepts and relations have attracted a lot of attention in the research community, leading to a number of tools facilitating the process of building and updating ontologies.
d'Aquin, Mathieu   +3 more
core  

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

open access: yesAdvanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi   +15 more
wiley   +1 more source

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

open access: yesAdvanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang   +20 more
wiley   +1 more source

Inexact Matching of Ontology Graphs Using Expectation-Maximization [PDF]

open access: green, 2009
Prashant Doshi   +2 more
openalex   +1 more source

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