Results 81 to 90 of about 48,631 (292)

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Successful rescue activation of unfertilized oocytes with calcium ionophore (A23187) in a case of recurrent ICSI fertilization failure: A case report

Asian Pacific Journal of Reproduction
Rationale: This case report describes a couple with recurrent fertilization failure despite undergoing multiple cycles of intracytoplasmic sperm injection (ICSI).
Akash More, Vilas Chimurkar, Namrata Choudhary, Dipali More, Sanket Mahajan   +4 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Biobanking efforts and new advances in male fertility preservation for rare and endangered species

Asian Journal of Andrology, 2015
Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
doaj   +1 more source

Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila

G3: Genes, Genomes, Genetics, 2020
At the oocyte-to-embryo transition the highly differentiated oocyte arrested in meiosis becomes a totipotent embryo capable of embryogenesis. Oocyte maturation (release of the prophase I primary arrest) and egg activation (release from the secondary ...
Emir E. Avilés-Pagán, Albert S. W. Kang, Terry L. Orr-Weaver   +2 more
doaj   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

The generation of live offspring from vitrified oocytes [PDF]

, 2011
Oocyte cryopreservation is extremely beneficial for assisted reproductive technologies, the treatment of infertility and biotechnology and offers a viable alternative to embryo freezing and ovarian grafting approaches for the generation of embryonic stem
Sanchez-Partida, Luis, Sumer, Huseyin, Sumer, H, Kelly, Richard, Lo, Camden, Kelly, RDW, Aharon, R, Moira K. O'Bryan, Kelly Richard D. W., Michael K. Holland, Camden Y. Lo, O'Bryan Moira K., St. John, Justin C., Justin C St John, Camden Y Lo, St John, Justin C., L. Gabriel Sanchez-Partida, Sumner, Huseyin, Sanchez-Partida L. Gabriel, John St., JC, St John, Justin, Sanchez-Partida, L. Gabriel, Richard D W Kelly, Michael K Holland, Moira K O'Bryan, St. John Justin C., Aharon Rotem, Sumer Huseyin, Lo Camden Y., Holland, Michael K., O'Bryan, Moira K., Rotem Aharon, Aharon, Rotem, Justin C. St. John, Holland Michael K., Sanchez-Partida, LG, O'Bryan, Moira, Lo, CY, Holland, MK, Lo, Camden Y., Huseyin Sumer, L Gabriel Sanchez-Partida, Richard D. W. Kelly, Kelly, Richard D. W., Sanchez-Partilda, L. Gabriel, O'Bryan, MK, Holland, Michael   +46 more
core   +1 more source

Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility

EMBO Molecular Medicine, 2023
Oocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)‐binding protein in Xenopus, mouse, and human oocytes and early embryos prior to zygotic genome ...
Weijie Wang, Jing Guo, Juanzi Shi, Qun Li, Biaobang Chen, Zhiqi Pan, Ronggui Qu, Jing Fu, Rong Shi, Xia Xue, Jian Mu, Zhihua Zhang, Tianyu Wu, Wenjing Wang, Lin Zhao, Qiaoli Li, Lin He, Xiaoxi Sun, Qing Sang, Ge Lin, Lei Wang   +20 more
doaj   +1 more source

Signalling mechanisms of mammalian oocyte activation [PDF]

Human Reproduction Update, 2002
Intensive study over the past 10 years has resulted in major advances in our understanding of the signalling mechanisms required for the transformation of the oocyte into an embryo capable of developing into a new individual. This review focuses on the signal transduction events that occur subsequent to the initial sperm-oocyte plasma membrane ...
openaire   +2 more sources

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source