Results 81 to 90 of about 79,883 (298)
Bi‐allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility
EMBO Molecular Medicine, 2023 Oocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)‐binding protein in Xenopus, mouse, and human oocytes and early embryos prior to zygotic genome ...
Weijie Wang +20 more
doaj +1 more source
Advanced Science, EarlyView.This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley +1 more source
Asian Pacific Journal of ReproductionRationale: This case report describes a couple with recurrent fertilization failure despite undergoing multiple cycles of intracytoplasmic sperm injection (ICSI).
Akash More +4 more
doaj +1 more source
Scrambled Eggs: Apoptotic cell clearance by non-professional phagocytes in the Drosophila ovary [PDF]
, 2017 This manuscript was supported by NIH grant R01 GM060574 to KM.
McCall, Kimberly, Serizier, Sandy B.
core +1 more source
Artificial oocyte activation: evidence for clinical readiness [PDF]
Reproductive BioMedicine Online, 2016 Artificial oocyte activation using Ca(2+)ionophores or similar compounds is a widely applied technique in IVF laboratories. This is all the more interesting as most of the agents aiming for intracellular Ca(2+) increase do not result in physiological Ca(2+) oscillations but much rather cause a single Ca(2+) transient.
Ebner, T., Montag, M.
openaire +2 more sources
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]
, 2001 To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P. +4 more
core
Oocyte destruction is activated during viral infection [PDF]
genesis, 2012 AbstractViral infection has been associated with a starvation‐like state in Drosophila melanogaster. Because starvation and inhibiting TOR kinase activity in vivo result in blocked oocyte production, we hypothesized that viral infection would also result in compromised oogenesis.
Travis C, Thomson +2 more
openaire +2 more sources
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, EarlyView.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
doaj +1 more source