Results 61 to 70 of about 1,544,426 (289)

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

EMBO Molecular Medicine
Oocyte activation is essential for successful fertilization and subsequent embryonic development. However, only a few disease-causing genes have been associated with sperm-derived oocyte activation failure, and the underlying molecular mechanisms and ...
Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang, Chen Lou, Sisi Li, Mingde Lin, Xin Li, Wenchao Xu, Jiaming Zhou, Peiran Hu, Zhendong Yao, Yuan Yuan, Jianzhong Sheng, Chen Zhang, Wei Yang, Youjiang Li, Hefeng Huang   +17 more
doaj   +1 more source

Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence [PDF]

, 2011
In vitro maturation of porcine oocytes has been intensively studied for many years. However, the in vitro maturation system is still inefficient to produce competent oocytes that can develop to viable embryos.
Yuan, Ye
core  

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Mice Oocytes Respond after Vitrification Followed by Artifical Activation Using a Various Concentration of Strontium Chloride and Cytochalasin B

Jurnal Veteriner, 2018
Oocyte vitrification is the important part of gamete preservation for further purpose. The objective of this study was to evaluate the response or development of vitrified-mice oocyte following activation using various concentrations of Strontium ...
Muhammad Rosyid Ridlo, Rini Widyastuti, Alkaustariyah Lubis, Mokhamad Fahrudin, Arief Boediono   +4 more
doaj  

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

ERK activation dynamics in maturing oocyte controls embryonic nuclear divisions in Caenorhabditis elegans

Cell Reports
Summary: ERK activity oscillates between sustained activation during oocyte formation and transient inactivation during oocyte maturation, fertilization, and early embryogenesis.
Han Bit Baek, Debabrata Das, Shin-Yu Chen, Hongyuan Li, Swathi Arur   +4 more
doaj   +1 more source

LACTATE DEHYDROGENASE ACTIVITY IN THE OOCYTES OF MAMMALS [PDF]

Reproduction, 1968
Summary. The mature oocyte dissected from the post-pubertal ovary has a lactate dehydrogenase activity similar to that found in the newly ovulated ovum in the mouse, rat, hamster and rabbit. There is very little interstrain or interbreed variation in ldh activity in the mouse and rabbit.
openaire   +2 more sources

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Successful rescue activation of unfertilized oocytes with calcium ionophore (A23187) in a case of recurrent ICSI fertilization failure: A case report

Asian Pacific Journal of Reproduction
Rationale: This case report describes a couple with recurrent fertilization failure despite undergoing multiple cycles of intracytoplasmic sperm injection (ICSI).
Akash More, Vilas Chimurkar, Namrata Choudhary, Dipali More, Sanket Mahajan   +4 more
doaj   +1 more source