Results 41 to 50 of about 48,631 (292)

oscillations for oocyte activation [PDF]

, 2015
Mammalian oocyte activation is mediated by cytosolic calcium (Ca2+) oscillations initiated upon delivery of a putative ‘sperm factor’ by the fertilizing sperm.
Sanders, Jessica R., Knaggs, Paul, Jessica R. Sanders, Buntwal, Luke, Swann, Karl, Junaid Kashir, Sanusi, Randa, David Sanders, Ashley, Peter, Adnan Bunkheila, Love, Daniel, Bunkheila, Adnan, Luke Buntwal, Daniel Love, Michail Nomikos, Karl Swann, Randa Sanusi, Sanders, David, Kashir, Junaid, F. Anthony Lai, Nomikos, Michail, Peter Ashley, Paul Knaggs, Lai, Francis   +23 more
core   +1 more source

Zinc Dynamics during Drosophila Oocyte Maturation and Egg Activation

iScience, 2020
Summary: Temporal fluctuations in zinc concentration are essential signals, including during oogenesis and early embryogenesis. In mammals, zinc accumulation and release are required for oocyte maturation and egg activation, respectively.
Qinan Hu, Francesca E. Duncan, Andrew B. Nowakowski, Olga A. Antipova, Teresa K. Woodruff, Thomas V. O'Halloran, Mariana F. Wolfner   +6 more
doaj   +1 more source

Review: Environment of the ovulatory follicle: modifications and use of biotechnologies to enhance oocyte competence and increase fertility in cattle

Animal, 2023
The oocyte is the basis of life, supporting development from a fertilized cell to an independent multicellular organism. The oocyte’s competence to drive the first cell cycles postfertilization are critical to embryonic survival and subsequent successful
Camila Bortoliero Costa, Trudee Fair, Marcelo M. Seneda   +2 more
doaj   +1 more source

Oocyte activation, phospholipase C zeta and human infertility. [PDF]

, 2010
BACKGROUND: Mammalian oocytes are activated by intracellular calcium (Ca(2+)) oscillations following gamete fusion. Recent evidence implicates a sperm-specific phospholipase C zeta, PLCζ, which is introduced into the oocyte following membrane fusion, as ...
Coward, Kevin, Coward, K, J. Parrington, B. Heindryckx, De Sutter, Petra, Heindryckx, B, C. Jones, Parrington, John, P. De Sutter, De Sutter, P, Parrington, J, K. Coward, Jones, C, Kashir, J, Heindryckx, Björn, J. Kashir   +15 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Identification of phospholipase activity in Rhinella arenarum sperm extract capable of inducing oocyte activation [PDF]

, 2013
Egg activation, which includes cortical granule exocytosis, resumption and completion of meiosis and pronuclear formation culminates in the first mitotic cleavage.
Minahk, Carlos Javier, Ajmat, María Teresa, Bühler, Marta Inés, Bonilla, Eduardo Federico, Sanchez Toranzo, Graciela   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Sperm contributions to oocyte activation: more that meets the eye [PDF]

, 2016
It is well known that for successful fertilization, oocyte activation is required, which involves a signal transduction cascade leading to the conversion of the oocyte to a diploid embryo.
Anifandis G., Messini C.I., Dafopoulos K., Daponte A., Messinis I.E.
core   +1 more source

Intracytoplasmic sperm injection with assisted oocyte activation resulting in successful pregnancies and live birth in couples with globozoospermia: A report of two cases

Journal of Human Reproductive Sciences, 2018
Globozoospermia, characterized by round-headed acrosomeless sperm, is a rare and severe form of teratozoospermia. We report a successful pregnancy in two cases of total globozoospermia after intracytoplasmic sperm injection (ICSI) with oocyte activation ...
Puneet Kaur Kochhar, Pranay Ghosh
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source