Results 21 to 30 of about 48,631 (292)

Mitochondrial Ca2 + Is Related to Mitochondrial Activity and Dynamic Events in Mouse Oocytes

Frontiers in Cell and Developmental Biology, 2020
Mitochondrial energy insufficiency is strongly associated with oocyte activation disorders. Ca2+, especially that in the mitochondrial matrix, plays a pivotal role in mitochondrial energy supplementation, but the underlying mechanisms are still only ...
Feng Wang, Feng Wang, Tie-Gang Meng, Tie-Gang Meng, Jian Li, Yi Hou, Shi-Ming Luo, Heide Schatten, Qing-Yuan Sun, Qing-Yuan Sun, Xiang-Hong Ou   +10 more
doaj   +1 more source

Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies

Frontiers in Cell and Developmental Biology, 2023
The recent COVID-19 pandemic led to many drastic changes in not only society, law, economics, but also in science and medicine, marking for the first time when drug regulatory authorities cleared for use mRNA-based vaccines in the fight against this ...
Wjdan S. Bafleh, Haia M. R. Abdulsamad, Sally M. Al-Qaraghuli, Riwa Y. El Khatib, Rawdah Taha Elbahrawi, Azhar Mohamud Abdukadir, Shaima M. Alsawae, Zakia Dimassi, Hamdan Hamdan, Hamdan Hamdan, Junaid Kashir, Junaid Kashir   +11 more
doaj   +1 more source

MicroRNA Activity Is Suppressed in Mouse Oocytes [PDF]

Current Biology, 2010
MicroRNAs (miRNAs) are small endogenous RNAs that typically imperfectly base pair with 3' untranslated regions (3'UTRs) and mediate translational repression and mRNA degradation. Dicer, which generates small RNAs in the miRNA and RNA interference (RNAi) pathways, is essential for meiotic maturation of mouse oocytes.
Ma, J., Flemr, M., Stein, P., Berninger, P., Malik, R., Zavolan, M., Svoboda, P., Schultz, R. M.   +7 more
openaire   +5 more sources

The Cyclin B2/CDK1 Complex Conservatively Inhibits Separase Activity in Oocyte Meiosis II

Frontiers in Cell and Developmental Biology, 2021
Recently, we have reported that the cyclin B2/CDK1 complex regulates homologous chromosome segregation through inhibiting separase activity in oocyte meiosis I, which further elucidates the compensation of cyclin B2 on cyclin B1’s function in meiosis I ...
Jian Li, Hong-Yong Zhang, Hong-Yong Zhang, Feng Wang, Feng Wang, Qing-Yuan Sun, Wei-Ping Qian, Wei-Ping Qian   +7 more
doaj   +1 more source

Preimplantation Developmental Competence of Bovine and Porcine Oocytes Activated by Zinc Chelation

Animals, 2022
After sperm-oocyte fusion, intracytoplasmic rises of calcium (Ca) induce the release of zinc (Zn) out of the oocyte (Zn sparks). Both phenomena are known to play an essential role in the oocyte activation process.
Juan P. Cabeza, Juan Cámera, Olinda Briski, Minerva Yauri Felipe, Daniel F. Salamone, Andrés Gambini   +5 more
doaj   +1 more source

Production of mouse offspring from inactivated spermatozoa using horse PLCζ mRNA

The Journal of Reproduction and Development, 2019
Improving artificial oocyte activation is essential for assisted reproduction or animal biotechnology that can obtain healthy offspring with a high success rate.
Yunosuke YAMAMOTO, Naoki HIROSE, Satoshi KAMIMURA, Sayaka WAKAYAMA, Junya ITO, Masatoshi OOGA, Teruhiko WAKAYAMA   +6 more
doaj   +1 more source

Regulation of the maternal-to-embryonic transition in "C. elegans" [PDF]

, 2012
Reproduction is a fundamental process of life which allows the survival of each species through the birth of young species members. Several modes of reproduction evolved and are classified into sexual and asexual reproduction.
Finger, Susanne
core   +1 more source

Oocyte activation induced by spermatids and the spermatozoa [PDF]

International Journal of Andrology, 2000
It has been reported that a sperm factor (SF) found in spermatozoa plays a critical role in fertilization. However, particulars of the oocyte‐activating and Ca2+ oscillation (Ca‐Os)‐inducing abilities of this SF remain unknown. We examined these abilities of spermatids in mouse, hamster and human by a mouse test (injection of spermatids into mouse ...
K, Yanagida, H, Yazawa, H, Katayose, Y, Kimura, S, Hayashi, A, Sato   +5 more
openaire   +2 more sources

Control of pluripotency during the oocyte-to-embryo transition in caenorhabditis elegans [PDF]

, 2015
The germline of Caenorhabditis elegans has been used as a model system to study the control of pluripotency in germ cells: through the mean of a genetic screen, from which most of the results of this thesis derived, different factors involved in the ...
Tocchini, Cristina
core   +1 more source

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism [PDF]

, 2012
DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases.
Cleghon Vaughn, Aman Singh (191216), Cleghon, V., Nathan Luebbering (191210), Sibbet Gary, Jingfen Han, Luebbering Nathan, Nathan Luebbering, Michael A J Ferguson, Singh, A., Aman Singh, Ferguson, M.A.J., Ferguson Michael A. J., Hong, W., Diego Miranda-Saavedra (36622), Michael A. J. Ferguson (166662), Jingfen Han, Han, J., Gary Sibbet (191221), Vaughn Cleghon (191224), Miranda-Saavedra Diego, Sibbet, G., Ferguson, M.A.J.; id_orcid, Han Jingfen, Miranda-Saavedra, D., Gary Sibbet, Luebbering, N., Diego Miranda-Saavedra, Michael A. J. Ferguson, Vaughn Cleghon, Singh Aman, Jingfen Han (191204)   +31 more
core   +1 more source