Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application [PDF]
Human Reproduction Open, 2022 AbstractBACKGROUNDOocyte activation deficiency (OAD) is attributed to the majority of cases underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte activation encompasses a series of concerted events, triggered by sperm-specific phospholipase C zeta (PLCζ), which elicits increases in free cytoplasmic calcium (Ca2+)
, Kevin Coward, Celine Jones
exaly +8 more sources
Assisted Oocyte Activation following Intracytoplasmic Sperm Injection: A Sensible Option for Infertile Couples with Severe Teratozoospermia [PDF]
International Journal of Fertility and Sterility, 2023 The intracytoplasmic sperm injection (ICSI) has significantly improved male factor infertility treatment; however, complete fertilization failure still occurs in 1-5% of ICSI treatment cycles mainly due to oocyte activation failure.
Marziyeh Tavalaee +3 more
doaj +4 more sources
Assisted oocyte activation is not beneficial for all patients with a suspected oocyte-related activation deficiency [PDF]
Human Reproduction, 2012 Despite the success of ICSI, total fertilization failure (TFF) still occurs in 1-3% of all ICSI cycles. ICSI followed by assisted oocyte activation (ICSI-AOA) can restore fertilization, most efficiently in cases of sperm-related fertilization deficiency.
Björn Heindryckx +2 more
exaly +5 more sources
Phospholipase C zeta: a hidden face of sperm for oocyte activation and early embryonic development [PDF]
Obstetrics & Gynecology ScienceOocyte activation is a fundamental event in mammalian fertilization and is initiated by a cascade of calcium signaling and oscillation pathways. Phospholipase C zeta (PLCζ) is involved in modulating cortical granule exocytosis, releasing oocyte meiotic ...
Soukaina Azil +4 more
doaj +5 more sources
Effects of assisted oocyte activation with calcium- ionophore and strontium chloride on in vitro ICSI outcomes [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Failed fertilization after intra-cytoplasmic sperm injection (ICSI) is mainly attributed to failed oocyte activation and can be overcome by artificial oocyte activation (AOA).
Marziyeh Norozi-Hafshejani +4 more
doaj +4 more sources
Oocyte activation deficiency: a role for an oocyte contribution? [PDF]
Human Reproduction Update, 2015 Infertility affects between 10 and 16% of couples worldwide. Twenty to 30% of cases of infertility are due to a male factor, 20-35% to a female factor, and 25-40% are due to both male and female factors. In ∼10-25% of cases, the precise underlying cause remains unclear.
Yeste, M +4 more
openaire +5 more sources
Assisted gamete treatment to pinpoint acquired meiotic maturity and overcome oocyte activation deficiency contributed by both gametes [PDF]
F&S Reports, 2023 Objective: To treat couples with total fertilization failure (TFF) based on a combined oocyte- and sperm-related oocyte activation deficiency by optimizing oocyte response to chemical activation with calcium ionophore. Design: Case report.
Philip Xie, B.Sc. +6 more
doaj +2 more sources
Chloroquine inhibits artificial oocyte activation induced by ethanol or Sr2+ but not by sperm in mice [PDF]
The Journal of Reproduction and DevelopmentCalcium release from the endoplasmic reticulum via sperm-derived phospholipase C zeta is crucial for oocyte activation during fertilization. Chloroquine (CQ) inhibits the increase in cytoplasmic calcium.
Tadashi YAMAZAKI +2 more
doaj +2 more sources
The Therapeutic and Diagnostic Potential of Phospholipase C Zeta, Oocyte Activation, and Calcium in Treating Human Infertility [PDF]
Pharmaceuticals, 2023 Oocyte activation, a fundamental event during mammalian fertilisation, is initiated by concerted intracellular patterns of calcium (Ca2+) release, termed Ca2+ oscillations, predominantly driven by testis-specific phospholipase C zeta (PLCζ).
Haia M. R. Abdulsamad +7 more
doaj +2 more sources
Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment [PDF]
Cell & Bioscience, 2021 The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components influence the oocyte activation during fertilization and are fundamental for normal embryo development ...
Mohammad Ishraq Zafar +2 more
doaj +2 more sources