Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application [PDF]
Human Reproduction Open, 2022 BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases underlying failure of ICSI cycles, the standard treatment for male factor infertility.
Junaid Kashir +2 more
exaly +9 more sources
Effects of assisted oocyte activation with calcium- ionophore and strontium chloride on in vitro ICSI outcomes [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Failed fertilization after intra-cytoplasmic sperm injection (ICSI) is mainly attributed to failed oocyte activation and can be overcome by artificial oocyte activation (AOA).
Marziyeh Norozi-Hafshejani +4 more
doaj +4 more sources
The Therapeutic and Diagnostic Potential of Phospholipase C Zeta, Oocyte Activation, and Calcium in Treating Human Infertility [PDF]
Pharmaceuticals, 2023 Oocyte activation, a fundamental event during mammalian fertilisation, is initiated by concerted intracellular patterns of calcium (Ca2+) release, termed Ca2+ oscillations, predominantly driven by testis-specific phospholipase C zeta (PLCζ).
Haia M. R. Abdulsamad +7 more
doaj +3 more sources
Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment [PDF]
Cell & Bioscience, 2021 The fertilizing spermatozoon is a highly specialized cell that selects from millions along the female tract until the oocyte. The paternal components influence the oocyte activation during fertilization and are fundamental for normal embryo development ...
Mohammad Ishraq Zafar +2 more
doaj +3 more sources
Assisted Oocyte Activation following Intracytoplasmic Sperm Injection: A Sensible Option for Infertile Couples with Severe Teratozoospermia [PDF]
International Journal of Fertility and Sterility, 2023 The intracytoplasmic sperm injection (ICSI) has significantly improved male factor infertility treatment; however, complete fertilization failure still occurs in 1-5% of ICSI treatment cycles mainly due to oocyte activation failure.
Marziyeh Tavalaee +3 more
doaj +3 more sources
Phospholipase C zeta: a hidden face of sperm for oocyte activation and early embryonic development [PDF]
Obstetrics & Gynecology ScienceOocyte activation is a fundamental event in mammalian fertilization and is initiated by a cascade of calcium signaling and oscillation pathways. Phospholipase C zeta (PLCζ) is involved in modulating cortical granule exocytosis, releasing oocyte meiotic ...
Soukaina Azil +4 more
doaj +4 more sources
SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency. [PDF]
Reproduction, 2022 Oocyte activation deficiency (OAD) remains the predominant cause of total/low fertilization rate in assisted reproductive technology. Phospholipase C zeta (PLCZ1) is the dominant sperm-specific factor responsible for triggering oocyte activation in ...
Jones C, Meng X, Coward K.
europepmc +2 more sources
Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future Directions. [PDF]
BiomoleculesDuring mammalian fertilization, repetitive intracellular Ca2+ increases known as Ca2+ oscillations occur. These oscillations are considered crucial for successful fertilization and subsequent embryonic development. Numerous researchers have endeavored to
Sugita H +5 more
europepmc +2 more sources
Assisted gamete treatment to pinpoint acquired meiotic maturity and overcome oocyte activation deficiency contributed by both gametes [PDF]
F&S Reports, 2023 Objective: To treat couples with total fertilization failure (TFF) based on a combined oocyte- and sperm-related oocyte activation deficiency by optimizing oocyte response to chemical activation with calcium ionophore. Design: Case report.
Philip Xie, B.Sc. +6 more
doaj +2 more sources
Ionophore application for artificial oocyte activation and its potential effect on morphokinetics: a sibling oocyte study. [PDF]
J Assist Reprod Genet, 2021 To evaluate whether ionophore application at the oocyte stage changes the morphokinetics of the associated embryos in cases of artificial oocyte activation.
Shebl O +7 more
europepmc +2 more sources