Results 31 to 40 of about 79,883 (298)
Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes [PDF]
, 1993 Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of a guanine nucleotide binding (G) protein-activated K+ channel. Current through the channel could be activated by acetylcholine or, if RNA encoding a neuronal 5HT1A receptor ...
Dascal, Nathan +5 more
core +1 more source
Animal, 2023 The oocyte is the basis of life, supporting development from a fertilized cell to an independent multicellular organism. The oocyte’s competence to drive the first cell cycles postfertilization are critical to embryonic survival and subsequent successful
Camila Bortoliero Costa +2 more
doaj +1 more source
Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise [PDF]
, 2011 The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy ...
Darzynkiewicz, Zbigniew +3 more
core +1 more source
eLife, 2017 The oocyte-to-embryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under precise developmental control. Despite presence of the catalytic PNG subunit and the
Masatoshi Hara +2 more
doaj +1 more source
Sperm Originated Chromatin Imprints and LincRNAs in Organismal Development and Cancer
iScience, 2020 Summary: Importance of sperm-derived transcripts and chromatin imprints in organismal development is poorly investigated. Here using an integrative approach, we show that human sperm transcripts are equally important as oocyte.
Santhilal Subhash +2 more
doaj +1 more source
Role of Na+/Ca2+ exchanger (NCX) in modulating postovulatory aging of mouse and rat oocytes.
PLoS ONE, 2014 We studied the role of the Na+/Ca2+ exchanger (NCX) in modulating oocyte postovulatory aging by observing changes in NCX contents and activities in aging mouse and rat oocytes.
Chuan-Xin Zhang +7 more
doaj +1 more source
Pharmaceuticals, 2023 Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation capacity.
Junaid Kashir +11 more
doaj +1 more source
LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]
, 2015 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T +8 more
core +1 more source
The Journal of Reproduction and Development, 2023 The mechanisms underlying postovulatory oocyte aging (POA) remain largely unknown. The expression of the calcium-sensing receptor (CaSR) in mouse oocytes and its role in POA need to be explored.
Rui YANG +7 more
doaj +1 more source
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
, 2007 Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas +30 more
core +3 more sources