Results 51 to 60 of about 316,539 (293)

Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Journal of Ovarian Research, 2023
Background Oocyte maturation arrest results in female infertility and the genetic etiology of this phenotype remains largely unknown. Previous studies have proven that cyclins play a significant role in the cell cycle both in meiosis and mitosis.
Congjing Wang, Meng Xi Chen, Yuan Zhang, Xue Bai, Qiqi Cao, Jian Han, Nana Zhang, Chun Zhao, Xiufeng Ling, Ximan Rui, Yichun Guan, Junqiang Zhang, Ran Huo   +12 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Maturation arrest of human oocytes at germinal vesicle stage

Journal of Human Reproductive Sciences, 2010
Maturation arrest of human oocytes may occur at various stages of the cell cycle. A total failure of human oocytes to complete meiosis is rarely observed during assisted conception cycles. We describe here a case of infertile couples for whom all oocytes
Zhi Qin Chen, Teng Xiao Ming, Hans Ingolf Nielsen   +2 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Optimal Allogeneic Platelet-Rich Plasma Concentration to Improve In Vitro Maturation of Germinal Vesicle Oocytes From Women With Polyendocrine Metabolic Ovarian Syndrome: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology
Background:In vitro maturation is a long-established technique used to obtain mature oocytes outside the human body. As an alternative to assisted reproductive technology (ART) protocols involving controlled ovarian stimulation (COS) followed by in vitro
Tiara Kusumaningtyas, Ita Fauzia Hanoum, Rr Vicki Nuri Prijayanti, Diany Ayu Suryaningtyas, Annisa Nur Islahi, Naila Nabila Rahmani, Intan Kusumaningtyas, Berli Kusuma, Anto Sawarno, Dewi Kartikawati Paramita, Djaswadi Dasuki   +10 more
doaj   +1 more source

Human oocyte maturation in vitro

The International Journal of Developmental Biology, 2012
Oocytes from medium-sized antral follicles have already completed their growth phase and, if released from the follicular environment and cultured in vitro, are able to resume the meiotic process and mature. However, in vitro maturation (IVM) does not entirely support all the nuclear and cytoplasmic changes that occur physiologically as an effect of ...
Coticchio, Giovanni, Dal-Canto, Mariabeatrice, Guglielmo, Maria-Cristina, Mignini-Renzini, Mario, Fadini, Rubens   +4 more
openaire   +4 more sources

Identification of optimal assisted aspiration conditions of oocytes for use in porcine in vitro maturation: a re-evaluation of the relationship between the cumulus oocyte complex and oocyte quality [PDF]

, 2020
The quality of porcine oocytes for use in IVF is commonly graded according to the number of layers of cumulus cells surrounding the oocyte; together these form the cumulus oocyte complex (COC).
Harvey, K.E., Rathje, C.C., Silvestri, S., Griffin D.K., Walling, G.A., Harvey, S.C., Ellis, P.J.I., Gould, R.L.   +7 more
core  

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

IL17 signaling promotes oocyte developmental competence acquisition during maturation

Cellular & Molecular Biology Letters
Background Defects in the acquisition of oocyte developmental competence during the maturation process causes subfertility or infertility in animals and humans.
Huaxing Zhao, Xiaohua He, Junsong Shi, Xiao Wu, Yalin Liang, Xingwang Wang, Zheng Ao, Xianjun Zhang, Yuxing Zhang, Yanan Li, Yiqian Zhang, Yazheng Dong, Jingfeng Peng, Yunfei Hou, Rong Zhou, Fang Zeng, Linjun Hong, Ting Gu, Huaqiang Yang, Jie Yang, Zheng Xu, Sixiu Huang, Gengyuan Cai, Zicong Li, Zhenfang Wu   +24 more
doaj   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source