Results 21 to 30 of about 15,361,986 (325)
Comprehensive mathematical modeling of age-dependent oocyte quality and quantity for predicting live birth rate [PDF]
Frontiers in EndocrinologyBackgroundAge-related decline in fertility is widely recognized. However, a quantitative evaluation of changes in oocyte quality and quantity remains insufficient.
Toshio Sujino +11 more
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Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality [PDF]
Human Reproduction Update, 2008 Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development ...
Gilchrist, R., Lane, M., Thompson, J.
openaire +4 more sources
Diffused Intra-Oocyte Hydrogen Peroxide Activates Myeloperoxidase and Deteriorates Oocyte Quality. [PDF]
PLoS ONE, 2015 Hydrogen peroxide (H2O2) is a relatively long-lived signaling molecule that plays an essential role in oocyte maturation, implantation, as well as early embryonic development. Exposure to relatively high levels of H2O2 functions efficiently to accelerate
Sana N Khan +7 more
doaj +2 more sources
Oocyte quality in women with infertility associated endometriosis
Gynecological Endocrinology, 2019 The mechanisms of endometriosis-related infertility remain still unknown. Endometriosis and clinical markers of oocyte quality are a very important problem of reproduction.
M. Orazov +4 more
exaly +2 more sources
Apoptosis maintains oocyte quality in aging Caenorhabditis elegans females. [PDF]
PLoS Genetics, 2008 In women, oocytes arrest development at the end of prophase of meiosis I and remain quiescent for years. Over time, the quality and quantity of these oocytes decreases, resulting in fewer pregnancies and an increased occurrence of birth defects.
Sara Andux, Ronald E Ellis
doaj +2 more sources
SDF-1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy-Enhanced Stress Granule Scavenging. [PDF]
Adv Sci (Weinh)SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Long R +12 more
europepmc +2 more sources
Oocyte development: it's all about quality [PDF]
Reproductive BioMedicine OnlineMammalian fertility depends on the production of an oocyte capable of fertilization and supporting early embryo development. This requires both cytoplasmic and nuclear, i.e. chromosomal, competence, processes that were initiated decades prior to ovulation.
Anderson, Richard A +2 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 It has been found that the quality of oocytes from obese women has been compromised and subsequent embryos displayed arrested development. The compromised quality may be either due to the poor or rich metabolic conditions such as imbalance or excession ...
Ranjha Khan +3 more
doaj +1 more source
Reorganization, specialization, and degradation of oocyte maternal components for early development
Reproductive Medicine and Biology, 2023 Background Oocyte components are maternally provided, solely determine oocyte quality, and coordinately determine embryo quality with zygotic gene expression.
Yuhkoh Satouh, Ken Sato
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Advancement of science, 2023 Significantly decreased H3K4 methylation in oocytes from aged mice indicates the important roles of H3K4 methylation in female reproduction. However, how H3K4 methylation regulates oocyte development remains largely unexplored.
Ning-Hua Mei +9 more
semanticscholar +1 more source