Results 21 to 30 of about 84,026 (244)

Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial [PDF]

Frontiers in Medicine
IntroductionPain is a highly prevalent symptom in the hospital setting, but treatment options remain limited. Harnessing the placebo effect in an ethical manner could provide a new possibility to reduce pain in clinical practice.
Matthijs de Leeuw, Mirjam Laager, Jens Gaab, Wilhelm Ruppen, Tobias Schneider   +4 more
doaj   +2 more sources

Combining mindfulness intervention and open-label placebo treatment for chronic pain: a protocol for a feasibility study [PDF]

Pilot and Feasibility Studies
Background Mindfulness-based interventions, such as mindfulness-based stress reduction (MBSR), are efficacious mind–body treatments for chronic pain, though their modest effect sizes suggest room for improvement.
Chung Jung Mun, Estrella Contreras, Yushu Xiao, Ryan Eckert, Alexandra Harting, Sathvika Damera, Iosef Perez, Hemant K. Pandey, Aram S. Mardian, Frank LoVecchio, Luana Colloca, Kelly E. Dunn, Michael Todd, Roger B. Fillingim, Mary C. Davis   +14 more
doaj   +2 more sources

Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial. [PDF]

Pain, 2021
Abstract It is commonly believed that blinding to treatment assignment is necessary for placebos to have an effect. However, placebos administered without concealment (ie, open-label placebos [OLPs]) have recently been shown to be effective in some conditions.
Lembo A, Kelley JM, Nee J, Ballou S, Iturrino J, Cheng V, Rangan V, Katon J, Hirsch W, Kirsch I, Hall K, Davis RB, Kaptchuk TJ.   +12 more
europepmc   +3 more sources

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis

BMJ Open Gastroenterology, 2021
Objective Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC).
Nicola Scott, Kurt Brown, Paul Peter Tak, Kathy Weisel, Scott Berger, Susanne Wang, Marcy Powell, Matthijs Broer, Clarissa Watts, Debra J Tompson, Susan W Burriss, Simon Hawkins, Kathy Abbott-Banner   +12 more
doaj   +1 more source

The Ethics of Open-Label Placebos in Pediatrics [PDF]

Pediatrics, 2017
* Abbreviation: ADHD — : attention-deficit/hyperactivity disorder Physicians have long debated the ethics of prescribing placebos as medical therapeutics. Placebos (sham treatments such as sugar pills or saline injections) are thought to elicit improvements in clinical outcomes by mimicking medical therapies, thereby improving patients ...
Brit, Trogen, Arthur, Caplan, Perri, Klass   +2 more
openaire   +2 more sources

Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch

Frontiers in Psychology, 2021
Introduction: Placebo and nocebo effects are positive and negative health outcomes that can be elicited by the psychosocial context. They can be mediated by expectations, and may emerge in somatic symptoms even when people are aware of these effects ...
Stefanie H. Meeuwis, Stefanie H. Meeuwis, Stefanie H. Meeuwis, Henriët van Middendorp, Henriët van Middendorp, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers   +10 more
doaj   +1 more source

Deceptive and non-deceptive placebos to reduce sadness: A five-armed experimental study

Journal of Affective Disorders Reports, 2022
Background: Placebo effects play an important role in psychopharmacological treatment of depression. Among the most potent mechanisms are positive treatment expectations. However, there is large heterogeneity in how they are induced.
Thilo Friehs, Winfried Rief, Julia A. Glombiewski, Julia Haas, Tobias Kube   +4 more
doaj   +1 more source

Open-label Placebos for Wound Healing: A Randomized Controlled Trial [PDF]

Annals of Behavioral Medicine, 2018
Open-label placebos are a novel treatment option, in which participants take placebos with full knowledge that they do not contain active medicine. Open-label placebo treatments have been shown to result in patient-reported symptom improvements, but they have not been tested on objectively measurable physiological outcomes such as wound healing.The ...
Ashwin, Mathur, Paul, Jarrett, Elizabeth, Broadbent, Keith J, Petrie   +3 more
openaire   +2 more sources

Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms

Scientific Reports, 2023
AbstractPlacebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically. To take this concept one step further, this study aimed at evaluating placebo effects without the use of a physical placebo, i.e., by ...
Buergler, Sarah, Sezer, Dilan, Bagge, Niels, Kirsch, Irving, Locher, Cosima, Carvalho, Claudia, Gaab, Jens   +6 more
openaire   +5 more sources

Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations [PDF]

Bioethics, 2016
AbstractThe doctor‐patient relationship is built on an implicit covenant of trust, yet it was not until the post‐World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses ...
Charlotte, Blease, Luana, Colloca, Ted J, Kaptchuk   +2 more
openaire   +2 more sources