Results 31 to 40 of about 156,514 (326)

Open-Label-Placebos can reduce pain, but not indigestion during gluten challenge in chronic pain patients [PDF]

open access: yesFrontiers in Psychology
BackgroundDietary interventions have become a management tool for chronic pain conditions over the past few decades. Certain diets, such as gluten-free diets, are perceived as particularly beneficial by patients, although there is no evidence to support ...
Lena Paschke-Dahl, Regine Klinger
doaj   +2 more sources

Effects of open-label placebos and self-monitoring in skin-picking disorder: a randomized crossover trial [PDF]

open access: yesFrontiers in Psychiatry
BackgroundSymptom reduction in skin-picking disorder (SPD) has previously been demonstrated using deceptive placebo treatments. However, to date, no study has investigated the effects of open-label placebos (OLPs) in this context.MethodFifty-two ...
Anne Schienle   +2 more
doaj   +2 more sources

Placebos in the era of open‐label trials: An update for clinicians [PDF]

open access: yesEuropean Journal of Clinical Investigation, 2018
Placebos have been used extensively by vast numbers of physicians, in a majority of clinical trials. Placebo effects involve behavioural, psychological and genetic factors and have been subject to ethical controversies stemming from the use of deception ...
I. Sagy   +3 more
semanticscholar   +3 more sources

Open-label placebo treatment of women with premenstrual syndrome: study protocol of a randomised controlled trial

open access: yesBMJ Open, 2020
IntroductionRecent evidence suggests that for certain clinical conditions, placebos can improve clinical outcomes even without deception. These so-called open-label placebos (OLPs) bear the advantage of a significant lower risk of adverse events and ...
Cosima Locher   +5 more
doaj   +2 more sources

Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial.

open access: yesPain, 2021
It is commonly believed that blinding to treatment assignment is necessary for placebos to have an effect. However, placebos administered without concealment (i.e., open-label placebos [OLP]) have recently been shown to be effective in some conditions ...
A. Lembo   +12 more
semanticscholar   +3 more sources

More than consent for ethical open-label placebo research

open access: yesJournal of Medical Ethics, 2020
Recent studies have explored the effectiveness of open-label placebos (OLPs) for a variety of conditions, including chronic pain, cancer-related fatigue and irritable bowel syndrome. OLPs are thought to sidestep traditional ethical worries about placebos
Laura Specker Sullivan
semanticscholar   +3 more sources

Reducing Emotional Distress with Open-Label Placebos: Assessing the Role of Motor Engagement in Pill Consumption [PDF]

open access: yesBehavioral Sciences
It has been posited that ingesting a pill constitutes a pivotal action that facilitates the effects of open-label placebos (OLPs: placebos honestly prescribed).
Anne Schienle, Wolfgang Kogler
doaj   +2 more sources

Lay perspectives of the open-label placebo rationale: a qualitative study of participants in an experimental trial

open access: yesBMJ Open, 2021
Objectives To analyse participants’ concepts about the open-label placebo (OLP) effect; to explore their views about the discussion points that are applied in conventional OLP trials and to examine their experiences of taking part in an OLP trial.Design ...
Cosima Locher   +5 more
doaj   +2 more sources

Efficacy of open-label placebos for premenstrual syndrome: a randomised controlled trial. [PDF]

open access: yesBMJ Evid Based Med
ObjectiveTo investigate the efficacy and safety of open-label placebos (OLP) in premenstrual syndrome (PMS).DesignRandomised controlled trial.SettingSwitzerland, 2018–2020.Participants150 women (18–45 years of age) with PMS or premenstrual dysphoric disorder.InterventionRandom assignment (1:1:1) to treatment as usual (TAU), OLP without treatment ...
Frey Nascimento A   +10 more
europepmc   +3 more sources

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