Results 101 to 110 of about 26,317,005 (275)

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

First Processing of the Complete Sentinel-1 SAR Archive: 10 Years of Global Sea State

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In this study, the sea state was estimated and analyzed by processing the ten-year worldwide Sentinel-1 synthetic aperture radar (SAR) archive 2014−2024. The approx. 15 Petabytes of data contain approx. 4.2 million SAR scenes, where approx.
Andrey Pleskachevsky, Bjorn Tings, Christoph Schnupfhagn, Stefan Wiehle, Sven Jacobsen   +4 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

3D imaging dataset of the human skeletal collection from Lucus Feroniae (Rome, Italy, 1st-3rd century CE)Zenodo

Data in Brief
This article presents a bioarchaeological dataset comprising high-resolution computed tomography (CT) scans of human skeletal remains from the Roman site of Lucus Feroniae (central Italy), dated to the Imperial period, specifically from the 1st to the ...
Barbara Coletti, Giulia Formichella, Carlotta Zeppilli, Antonio Profico, Giorgio Manzi, Ileana Micarelli   +5 more
doaj   +1 more source

Open Test Archive - Repositorium mit Zugang zu mehr Open-Access-Tests

Das Open Test Archive ist ein Produkt des Leibniz-Instituts für Psychologie und umfasst derzeit 234 Testinstrumente, die online auf der Webseite www.testarchiv.eu heruntergeladen werden können.
Karadere, Gülay
core   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Recommendations for the Open Access Transition

, 2016
The following “Recommendations for Open Access transition” have been compiled by the Ad-hoc workgroup “Open-Access-Gold” in the priority initiative “Digital Information” of the Alliance of Science Organizations in Germany .
Hanig, Kristina, Geschuhn, Kai, Schäffler, Hildegard, Hillenkötter, Christine, Scholze, Frank, Timm, Arnulf, Pampel, Heinz, Bruch, Christoph, Tullney, Marco, Scheiner, Annette, Stanek, Ursula   +10 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Implantación de la Open Archives Initiative en España.

Inf. Res., 2008
Introduction. The article approaches the situation in Spain of actions related to the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH), used for the harvesting and diffusion of metadata for documents. The type of digital libraries, under this protocol, is experiencing worldwide development with institutional repositories developed ...
Peset, Fernanda, Ferrer-Sapena, Antonia
openaire   +2 more sources