Results 81 to 90 of about 26,317,005 (275)

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

The Organization for Human Brain Mapping Time Machine: A freely accessible archive of Annual Meeting talks on YouTube

Aperture Neuro
Since 1995, the Organization for Human Brain Mapping (OHBM) Annual Meeting has provided a critical platform for sharing the latest developments in brain mapping.
Alfie Wearn, Kevin R. Sitek, Sofie L. Valk, Stephanie J. Forkel   +3 more
doaj   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

The Next Information Revolution - How Open Access will Transform Scholarly Communications [PDF]

, 2005
Complaints about spiralling serials costs, lack of service from large commercial publishers, and the inability to meet the information needs of researchers are not new.
David C Prosser, Prosser, David C.
core   +1 more source

The Role of the Patriarch Hermogenes Written Applications in Organization of Zemstvo Militia, 1611

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017
The article deals with a controversial issue in historical science about what specific role played by the Patriarch Hermogenes in the organization of the zemstvo movement during the Interregnum, at the beginning of the folding of the national militia at ...
Nataliya V. Rybalko, Evgeniya G. Dmitrieva, Elena S. Maleeva   +2 more
doaj   +1 more source

Die Open Archives Initiative (Vortrag)

, 2002
Nachdem vor zwei Jahren die Open Archives Initiative die Protokollversion 1.0 veröffentlicht hat, wurde im Juni 2002 nach ausführlichen Test die Version 2.0 veröffentlicht, die eine stabile Basis für die Zukunft sein soll. Die Erfolgsbilanz von OAI weist weltweit inzwischen mehr als 70 registrierte Archive nach.
openaire   +2 more sources

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Archiving scientific literature : an experience with e-prints archive software [PDF]

, 2002
The world of academic publishing is undergoing many changes. Paper based publishing is being supplemented by electronic archives. In certain areas, preprint distribution has completely moved away from the paper-based system in to a fully electronic ...
Jayakanth, Francis, Singhal, Madhuresh
core   +1 more source