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Maintenance of chromatin states: an open-and-shut case
Current Opinion in Cell Biology, 2003The traditional view of chromatin envisions two states: one is 'active' and accessible to nucleases, whereas the other is 'silent' and relatively inaccessible. Recent evidence that combinations of diverse histone tail modifications represent a spectrum of chromatin states challenges this simple view.
Danielle, Vermaak +2 more
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The Chromatin of Active Genes Is Not in a Permanently Open Conformation
Journal of Molecular Biology, 2009Quantitative measurements of local chromatin accessibility to DNase I in 15-day chicken embryo erythrocyte nuclei have been performed using a range of nuclease concentrations and real-time TaqMan PCR to monitor the loss of short ( approximately 80 bp) amplicons. At the beta-globin locus, well-established DNase I hypersensitive sites stand out against a
Sapojnikova, N. +4 more
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Combined Analysis of mRNA Expression and Open Chromatin in Microglia
2023The advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity of microglial cell states in the homeostatic and diseased brain. This includes rather complex proteomic, metabolomic, morphological, transcriptomic, and epigenetic adaptations to external stimuli and ...
Scholz, Rebekka +4 more
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The EMBO Journal, 1993
Histone H1 preferentially and cooperatively binds scaffold-associated regions (SARs) in vitro via specific interactions with the numerous short A + T-rich tracts (A-tracts) contained in these sequences. Selective titration of A-tracts by the oligopeptide distamycin abolishes this interaction and results in a redistribution of H1.
Kaes, Emmanuel +3 more
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Histone H1 preferentially and cooperatively binds scaffold-associated regions (SARs) in vitro via specific interactions with the numerous short A + T-rich tracts (A-tracts) contained in these sequences. Selective titration of A-tracts by the oligopeptide distamycin abolishes this interaction and results in a redistribution of H1.
Kaes, Emmanuel +3 more
openaire +3 more sources
Effects of allele-specific open chromatin
Science, 2020Neurogenomics Genetic variants in noncoding regions of the genome may underlie the development of disease. However, we are just beginning to tease apart the function of such variants associated with neuropsychiatric disease. Using five types of neural progenitor cells derived from 20 human induced pluripotent stem cell lines, Zhang et al.
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MH-seq for Functional Characterization of Open Chromatin in Plants
Trends in Plant Science, 2020Qingquan Zhu, Wenli Zhang
exaly