Results 141 to 150 of about 2,077,918 (304)

PRIVATE SCHOOL TEACHERS’ PERSPECTIVES ON DIGITAL BADGE SYSTEM ACCEPTANCE: A Q METHODOLOGY STUDY

Malaysian Journal of Learning and Instruction
Purpose – This Q methodology study explores teachers' views on using a digital badge system in two private schools. It aims to understand how teachers interpret, use, and value this system for personalising their professional development and validating ...
Albert Wee Po Ng, Harvinder Kaur Dharam Singh   +1 more
doaj   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Predicting students’ academic progress and related attributes in first-year medical students: an analysis with artificial neural networks and Naïve Bayes

BMC Medical Education
Background Dropout and poor academic performance are persistent problems in medical schools in emerging economies. Identifying at-risk students early and knowing the factors that contribute to their success would be useful for designing educational ...
Diego Monteverde-Suárez, Patricia González-Flores, Roberto Santos-Solórzano, Manuel García-Minjares, Irma Zavala-Sierra, Verónica Luna de la Luz, Melchor Sánchez-Mendiola   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Open Geography Education

Instructors and professors of geography and related disciplines will want to take advantage of the resources made available by Open Geography Education, a website "dedicated to providing free, open curriculum and resources to anybody who is ...

core  

Supporting Open Practices with Teachers in Zambia

Journal of Learning for Development, 2019
This paper demonstrates how the features and affordances of open learning have been developed in new and productive ways to provide school-based continuing professional development for teachers in Zambia. It presents and critically reviews data from 200
Kris Stutchbury, Lore Gallastegi, Clare Woodward   +2 more
doaj  

Engagement of health and social care employers in professional regulatory fitness to practise – missed regulatory and organisational opportunities?

BMC Health Services Research
Background Health and social care professional regulators are organisations that ensure their registrants have the correct qualifications and experience to practise in their profession.
Louise M. Wallace, Mari Greenfield
doaj   +1 more source

Open access, open education resources and open data in Uganda. [PDF]

Pan Afr Med J, 2015
Salvo ID, Mwoka M, Kwaga T, Rukundo PA, Ernest DS, Osaheni LA, John K, Shafik K, de Sousa AM.   +8 more
europepmc   +1 more source