Results 131 to 140 of about 636,394 (303)

Codebook for Qualitative Data Analysis of Factors and Conditions of Citizen Engagement with Open Government Data

, 2020
The dataset contains the codebook used in an article titled "Citizen Engagement with Open Government Data: Lessons learned from Indonesia’s Presidential Election" submitted to the Transforming Government: People, Process and Policy ...
Zuiderwijk, A.M.G. (Anneke), Purwanto, A. (Arie), Janssen, M.F.W.H.A. (Marijn)   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Open data for development : building an inclusive data revolution - period covered 1st April 2019 - 31st March 2020

, 2020
Open Data for Development (OD4D) is the leading global partnership created to advance open data innovation and use around the world. This annual report provides an overview on the global context, trends, and issues influencing the program, and summarizes
Open Data for Development Network
core  

Funding Open Data

, 2018
Open government data are fast becoming entrenched in our society. However, even though open government data may be “free”, it is not “gratis”. It takes substantial human and financial resources not only to collect and maintain government data, but also ...
Welle Donker, F.M. (author), Frederika Welle Donker   +1 more
core   +1 more source

[Creating Impact from Open Government Data: What Are the Keys to Success?] [PDF]

HMD Prax Wirtsch Inform, 2021
Neumann O, Mettler T.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Breaking Public Administrations' Data Silos: the Case of Open-DAI, and a Comparison between Open Data Platforms

, 2014
An open reuse of public data and tools can turn the government into a powerful ‘platform' also involving external innovators. However, the typical information system of a public agency is not open by design.
Morando, Federico, Raimondo Iemma, Iemma, Raimondo, Osella, Michele, Michele Osella   +4 more
core   +2 more sources

Research on Linked Open Government Data and Application

Dianxin kexue, 2012
Open government data（OGD）is growing steadily and it has been a vital communication channel between government and citizens. Government data published by linked data technology can promote transparency and even improve reuse rate of data.
Yuanming Yuan, Chanle1 Wu, Haojun Ai
doaj   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source