Results 121 to 130 of about 2,286,604 (339)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Navigating the open innovation paradox: an integrative framework for adopting open innovation in pharmaceutical R&D in developing countries. [PDF]

J Technol Transf, 2022
Bhatnagar B, Dörfler V, MacBryde J.
europepmc   +1 more source

Structural Change, Growth and Bazaar Effects in the Single EU Market [PDF]

This paper analyzes the link between structural change, growth and bazaar effects in the context of open economies. At first we consider the theoretical basis of structural change and discuss the interdependencies between trade, foreign direct investment
Dora Borbély, Paul J.J. Welfens
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Impact of environmental sustainability on open innovation in SMEs: An empirical study considering the moderating effect of gender. [PDF]

Heliyon, 2023
Sarango-Lalangui P, Castillo-Vergara M, Carrasco-Carvajal O, Durendez A.   +3 more
europepmc   +1 more source

Open Innovations as a form of Customer Value Co-Creation [PDF]

, 2021
Krystyna Mazurek-Łopacińska
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Enhancement, brightening and control of radiative emission of dark exciton in WSe2 monolayer by plasmonic effect

npj 2D Materials and Applications
Dark excitons in two-dimensional (2D) transition metal dichalcogenide semiconductors (TMDs) have long radiative lifetimes, making them promising for quantum information and optoelectronics.
Adlen Smiri, F. R. Pratama, Takeshi Nakanishi   +2 more
doaj   +1 more source

Multi-disciplinary Perspectives on Citizen Science—Synthesizing Five Paradigms of Citizen Involvement

Citizen Science: Theory and Practice
Research on Open Innovation in Science (OIS) investigates how open and collaborative practices influence the scientific and societal impact of research. Since 2019, the OIS Research Conference has brought together scholars and practitioners from diverse ...
Susanne Beck, Dilek Fraisl, Marion Poetz, Henry Sauermann   +3 more
doaj   +1 more source

Rethinking Open Innovation Beyond the Innovation Funnel [PDF]

Technology Innovation Management Review, 2013
In his article, I first argue that open innovation can be applied in situations where companies do not themselves develop new products or services.
Wim Vanhaverbeke
doaj