Results 101 to 110 of about 1,756,114 (295)

RANS Simulation of Turbulent Diffusive Combustion using Open Foam

Journal of Applied Fluid Mechanics, 2016
Schemes to write the flow equations in discreet form, solution solvers, pre and post data processing utilitiesprovidedbyOpenFoamlibraries, areusedtobuildafinitevolumeexecutableforsimulatinga low speed, turbulent and rate controlled diffusive CH4-Air combustion. Unsteady Favre’s averaged turbulent conservation equations (total mass, momentum, energy and
Gutierrez Marcantoni, Luis Felipe, Tamagno, Jose Pedro, Elaskar, Sergio Amado   +2 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Toward a Multi-Layer Defence Framework for Securing Near-Real-Time Operations in Open RAN

IEEE Open Journal of the Communications Society
Securing the near-real-time (near-RT) control operations in Open Radio Access Networks (Open RAN) is increasingly critical, yet remains insufficiently addressed, as new runtime threats target the control loop while the system is operational.
Hamed Alimohammadi, Samara Mayhoub, Sotiris Chatzimiltis, Mohammad Shojafar, Muhammad Nasir Mumtaz Bhutta   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Empowering the 6G Cellular Architecture With Open RAN

IEEE Journal on Selected Areas in Communications
Innovation and standardization in 5G have brought advancements to every facet of the cellular architecture. This ranges from the introduction of new frequency bands and signaling technologies for the radio access network (RAN), to a core network underpinned by micro-services and network function virtualization (NFV).
Michele Polese, Mischa Dohler, Falko Dressler, Melike Erol-Kantarci, Rittwik Jana, Raymond Knopp, Tommaso Melodia   +6 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Energy Efficiency in Open RAN: RF Channel Reconfiguration Use Case

IEEE Access
Recently, energy efficiency (EE) has been pointed out as one of the key requirements within mobile networks. The development of intelligent algorithms providing Radio Access Networks (RAN) with EE features is possible when having access to the Key ...
Marcin Hoffmann, Marcin Dryjanski
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

High-Throughput Accelerator for Exact-MMSE Soft-Output Detection in Open RAN Systems

IEEE Access
Open Radio Access Networks (Open RANs), realized fully in software, require excessive computing resources to support time-sensitive signal-processing algorithms in the physical layer.
Thomas James Thomas, Konstantinos Nikitopoulos   +1 more
doaj   +1 more source

Children's Health: Evaluating the Impact of Digital Technology. Final Report for Sunderland City Council. [PDF]

, 2011
EXECUTIVE SUMMARY The Children’s Health project sponsored by the City of Sunderland Digital Challenge project examined the impact of providing health-focused digital technologies to children aged 11-15 years, in terms of their usage and requirements of ...
Edwards, Helen, McDonald, Sharon, Zhao, Tingting   +2 more
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