Results 81 to 90 of about 262,816 (254)

Open vs. Commercial 5G SA Deployments: Performance Assessment

Technologies
Open-source and commercial fifth-generation (5G) deployments are difficult to compare because they are built for different goals and reported under different conditions, which slows down validation and technology transfer from research to practice.
Teodora-Cristina Stoian, Razvan-Marius Mihai, Ekaterina Svertoka, Alexandru Martian, Cristian Patachia-Sultanoiu   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PACIFISTA: Conflict Evaluation and Management in Open RAN

IEEE Transactions on Mobile Computing
15 pages, 18 figures, 7 ...
Pietro Brach del Prever, Salvatore D'Oro, Leonardo Bonati, Michele Polese, Maria Tsampazi, Heiko Lehmann, Tommaso Melodia   +6 more
openaire   +2 more sources

Toward a Multi-Layer Defence Framework for Securing Near-Real-Time Operations in Open RAN

IEEE Open Journal of the Communications Society
Securing the near-real-time (near-RT) control operations in Open Radio Access Networks (Open RAN) is increasingly critical, yet remains insufficiently addressed, as new runtime threats target the control loop while the system is operational.
Hamed Alimohammadi, Samara Mayhoub, Sotiris Chatzimiltis, Mohammad Shojafar, Muhammad Nasir Mumtaz Bhutta   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Energy Efficiency in Open RAN: RF Channel Reconfiguration Use Case

IEEE Access
Recently, energy efficiency (EE) has been pointed out as one of the key requirements within mobile networks. The development of intelligent algorithms providing Radio Access Networks (RAN) with EE features is possible when having access to the Key ...
Marcin Hoffmann, Marcin Dryjanski
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

RAN Virtualization: How Hard Is It to Fully Achieve?

IEEE Access
Radio Access Network (RAN) virtualization stands as a pivotal concept in the realm of 5G networks and beyond. It emerges as a viable solution not only to address energy cost concerns but also to optimize material and radio resource management.
Mihia Kassi, Soumaya Hamouda
doaj   +1 more source