Results 71 to 80 of about 346,866 (255)

A Next-Generation Cyber-Range Framework for O-RAN and 6G Security Validation

Future Internet
The evolution towards an Open Radio Access Network (O-RAN) and 6G introduces unprecedented openness and intelligence in mobile networks, alongside significant security challenges.
Evangelos Chaskos, Nicholas Kolokotronis, Stavros Shiaeles   +2 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Security Threats to xApps Access Control and E2 Interface in O-RAN

IEEE Open Journal of the Communications Society
Open Radio Access Networks (O-RANs) represent a novel wireless access network architecture that decomposes traditional RAN functions and makes them openly accessible.
Cheng-Feng Hung, You-Run Chen, Chi-Heng Tseng, Shin-Ming Cheng   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Empowering Next-Gen Networks: AI-Driven Autonomy in O-RAN and SON Architectures

IEEE Access
Wireless communication plays a crucial role in evolving next-generation networks. Open Radio Access Networks (O-RAN), Self-Organizing Networks (SON), and Artificial Intelligence (AI)-driven automation are set to revolutionize network operations by ...
Dalia Abouelmaati, Alireza Esfahani, Shidrokh Goudarzi, Shahid Mumtaz   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Advancing Next Generation Wireless Networks With Digital Twin: Construction, Validation, and Real-World Applications on an Indoor Over-the-Air Testbed

IEEE Access
Digital Twin (DT) technology has recently emerged as a powerful tool with the potential to revolutionize wireless systems as it enables accurate simulations, better decision-making, and tangible operational improvements.
Berk Akgun, Aditya Jolly, Balwinder Sachdev, Divya Ravichandran, Roohollah Amiri, Vikas Jain, Muruganandam Jayabalan, Yitao Chen, Hetal Pathak, Vinay Chande, Mohammad Fahim, Srinivas Yerramalli, Rupesh Acharya, Chandresh Tiwari, Connor Woodahl, Arumugam Kannan, Xiaoxia Zhang, Deepu Alex, Abhishek Kumar, Hai Hong, John Boyd, Rajat Prakash, Suresh Babu Mummana, Sumanth Govindappa, James Y. Wilson, Jalaj Swami, Vivian Pham, Andrei Vadeanu, Gilad Govrin   +28 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source