Results 71 to 80 of about 262,816 (254)

Security Threats to xApps Access Control and E2 Interface in O-RAN

IEEE Open Journal of the Communications Society
Open Radio Access Networks (O-RANs) represent a novel wireless access network architecture that decomposes traditional RAN functions and makes them openly accessible.
Cheng-Feng Hung, You-Run Chen, Chi-Heng Tseng, Shin-Ming Cheng   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Empowering Next-Gen Networks: AI-Driven Autonomy in O-RAN and SON Architectures

IEEE Access
Wireless communication plays a crucial role in evolving next-generation networks. Open Radio Access Networks (O-RAN), Self-Organizing Networks (SON), and Artificial Intelligence (AI)-driven automation are set to revolutionize network operations by ...
Dalia Abouelmaati, Alireza Esfahani, Shidrokh Goudarzi, Shahid Mumtaz   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Advancing Next Generation Wireless Networks With Digital Twin: Construction, Validation, and Real-World Applications on an Indoor Over-the-Air Testbed

IEEE Access
Digital Twin (DT) technology has recently emerged as a powerful tool with the potential to revolutionize wireless systems as it enables accurate simulations, better decision-making, and tangible operational improvements.
Berk Akgun, Aditya Jolly, Balwinder Sachdev, Divya Ravichandran, Roohollah Amiri, Vikas Jain, Muruganandam Jayabalan, Yitao Chen, Hetal Pathak, Vinay Chande, Mohammad Fahim, Srinivas Yerramalli, Rupesh Acharya, Chandresh Tiwari, Connor Woodahl, Arumugam Kannan, Xiaoxia Zhang, Deepu Alex, Abhishek Kumar, Hai Hong, John Boyd, Rajat Prakash, Suresh Babu Mummana, Sumanth Govindappa, James Y. Wilson, Jalaj Swami, Vivian Pham, Andrei Vadeanu, Gilad Govrin   +28 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

DRL-Based RAN Slicing With Efficient Inter-Slice Isolation in Tactical Wireless Networks

IEEE Open Journal of Vehicular Technology
The next generation of tactical networks (TNs) is poised to further leverage the key enablers of 5G and beyond 5G (B5G) technology, such as radio access network (RAN) slicing and the open RAN (O-RAN) paradigm, to unlock new architectural options for ...
Abderrahime Filali, Diala Naboulsi, Georges Kaddoum   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source