Results 71 to 80 of about 255,903 (282)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Survey on 5G Second Phase RAN Architectures and Functional Splits [PDF]

, 2022
The Radio Access Network (RAN) architecture evolves with different generations of mobile communication technologies and forms an indispensable component of the mobile network architecture. The main component of the RAN infrastructure is the base station,
Velez, Fernando, Wagen, Jean-Frédéric, OdetAlla, Hatem, Mihovska, Albena Dimitrova, Flizikowski, Adam, Bahram, Khan, Nidhi, Nidhi   +6 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Enhancing Open RAN Digital Twin Through Power Consumption Measurement [PDF]

The increasing demand for high-speed, ultra-reliable and low-latency communications in 5G and beyond networks has led to a significant increase in power consumption, particularly within the Radio Access Network (RAN).
Al-Tahmeesschi, Ahmed Abdulkareem J, Shackleton, Josh, Ahmadi, Hamed, Chetty, Swarna Bindu, Chu, Yi, Rahmani, Mostafa, Grace, David   +6 more
core  

Open RAN e os desafios da sua experimentação em plataformas de código aberto

, 2022
A arquitetura Open RAN (O-RAN) e as especificações da O-RAN Alliance têm o potencial de promover Redes de Acesso via Rádio, ou Radio Access Networks (RANs) em inglês, virtualizadas e desagregadas, conectadas por meio de interfaces não-proprietárias e ...
Ferreira, Gabriel de Carvalho, Barreto, Priscila América Solís Mendez, Saraiva Júnior, Raimundo G., Carvalho, Paulo Henrique Portela de   +3 more
core   +1 more source

Multi-UE 5G RAN Measurements: A Gamut of Architectural Options

IEEE Access
The Radio Access Network (RAN) of Fifth Generation (5G) communication systems critically influences the overall performance and cost of a 5G system.
Andreas Ingo Grohmann, Mauri Seidel, Sebastian A. W. Itting, Ray-Guang Cheng, Martin Reisslein, Frank H. P. Fitzek   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Twinning Commercial Network Traces on Experimental Open RAN Platforms [PDF]

While the availability of large datasets has been instrumental to advance fields like computer vision and natural language processing, this has not been the case in mobile networking.
Shirkhani, Ravis, Bonati, Leonardo, Maxenti, Stefano, Melodia, Tommaso, Fiandrino, Claudio, Polese, Michele, D'Oro, Salvatore   +6 more
core   +3 more sources

Open RAN testbeds with controlled air mobility

Computer Communications
With its promise of increasing softwarization, improving disaggregability, and creating an open-source based ecosystem in the area of Radio Access Networks, the idea of Open RAN has generated rising interest in the community. Even as the community races to provide and verify complete Open RAN systems, the importance of verification of systems based on ...
Magreth Mushi, Yuchen Liu 0001, Shreyas Sreenivasa, Özgür Özdemir, Ismail Güvenç, Mihail L. Sichitiu, Rudra Dutta, Russ Gyurek   +7 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source