Results 111 to 120 of about 1,440,104 (391)

Standardized annotation of translated open reading frames [PDF]

Nature Biotechnology, 2022
Jonathan M. Mudge, Jorge Ruiz-Orera, John R. Prensner, Marie A. Brunet, Ferriol Calvet, Irwin Jungreis, Jose Manuel Gonzalez, Michele Magrane, Thomas F. Martinez, Jana Felicitas Schulz, Yucheng T. Yang, M. Mar Albà, Julie L. Aspden, Pavel V. Baranov, Ariel A. Bazzini, Elspeth Bruford, Maria Jesus Martin, Lorenzo Calviello, Anne-Ruxandra Carvunis, Jin Chen, Juan Pablo Couso, Eric W. Deutsch, Paul Flicek, Adam Frankish, Mark Gerstein, Norbert Hubner, Nicholas T. Ingolia, Manolis Kellis, Gerben Menschaert, Robert L. Moritz, Uwe Ohler, Xavier Roucou, Alan Saghatelian, Jonathan S. Weissman, Sebastiaan van Heesch   +34 more
openaire   +4 more sources

An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1

Frontiers in Genetics, 2020
Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipogenesis. The PPARγ gene produces various transcripts with different 5′-untranslated regions (5′ UTRs) because of alternative promoter usage and splicing.
Yankai Chu, Yankai Chu, Yankai Chu, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Guangwei Ma, Guangwei Ma, Guangwei Ma, Tingting Cui, Tingting Cui, Tingting Cui, Xiaohong Yan, Xiaohong Yan, Xiaohong Yan, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +20 more
doaj   +1 more source

An upstream open reading frame modulates ebola virus polymerase translation and virus replication. [PDF]

PLoS Pathogens, 2013
Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific
Reed S Shabman, Thomas Hoenen, Allison Groseth, Omar Jabado, Jennifer M Binning, Gaya K Amarasinghe, Heinz Feldmann, Christopher F Basler   +7 more
doaj   +1 more source

Conservation and loss of the ERV3 open reading frame in primates

Genomics, 2004
The human endogenous retrovirus ERV3 possesses an open reading frame for a truncated envelope, which is expressed as mRNA and protein. Here we examine the env sequence in primates for evidence of evolutionary conservation. ERV3 sequences were amplified by PCR from genomic DNA of great ape and Old World primates but not from New World primates or ...
C. A. Hervé, Patrick J Venables, G Forrest, R Löwer, D. J. Griffiths   +4 more
openaire   +3 more sources

A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]

, 2000
The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge, Chevalier, Catherine, Ielpi, Luis, Labigne, Agnès, O'Rourke, Eyleen J., Radicella, Juan Pablo   +5 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Fusion of the Tumor-Suppressor Gene CHEK2 and the Gene for the Regulatory Subunit B of Protein Phosphatase 2 PPP2R2A in Childhood Teratoma

Neoplasia: An International Journal for Oncology Research, 2006
We characterized the molecular genetic consequences of a balanced chromosome translocation t(8;22)(p21; q12), which occurred as the sole cytogenetic aberration in short-term cultured cells from an intrathoracic mature teratoma in a 15-year-old girl ...
Yuesheng Jin, Fredrik Mertens, Carl-Magnus Kullendorff, loannis Panagopoulos   +3 more
doaj   +1 more source

Peptidomic discovery of short open reading frame-encoded peptides in human cells

Nature Chemical Biology, 2012
The amount of the transcriptome that is translated into polypeptides is of fundamental importance. We developed a peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells. We identified 90 SEPs, 86 of which are novel, the
Sarah A. Slavoff, Andrew J. Mitchell, Adam G Schwaid, M. Cabili, Jiao Ma, J. Levin, Amir Karger, B. Budnik, J. Rinn, A. Saghatelian   +9 more
semanticscholar   +1 more source

Cloning, expression, and localization of a rat brain high-affinity glycine transporter [PDF]

, 1992
A cDNA clone encoding a glycine transporter has been isolated from rat brain by a combined PCR and plaque-hybridization strategy. mRNA synthesized from this clone (designated GLYT1) directs the expression of sodium-and chloride-dependent, high-affinity ...
Brecha, Nicholas, Davidson, Norman, Guastella, John, Lester, Henry A., Weigmann, Christine   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source