Integration of genomics and transcriptomics highlights the crucial role of chromosome 5 open reading frame 34 in various human malignancies. [PDF]
Li Y +6 more
europepmc +1 more source
The Immediate-Early Gene Product Encoded by Open Reading Frame 57 of Herpesvirus Saimiri Modulates Gene Expression at a Posttranscriptional Level [PDF]
Adrian Whitehouse +2 more
openalex +1 more source
TIGAR (chromosome 12 open reading frame 5)
Human TIGAR protein consists of 270 arninoacids, with a molecular weight of 30063 Da. It is cornposed of a bisphosphatase active site in which two histidines, His-11 and His-198, and one glutamic acid, Glu-1 02, are key residues for its function TIGAR catalytic domain belongs to the histidine phosphatase superfamily of proteins, a conserved group of ...
Simon Molas, Helga +5 more
openaire +1 more source
At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis
Stem cell mechanosensitivity governs lineage commitment through mechanotransduction, but capturing these transient changes in living cells remains challenging. Advanced atomic force microscopy enables high‐resolution analysis of mechanical properties, real‐time protein distribution, and gene expression, offering fresh insights into cell‐environment ...
Kaiwen Zhang +5 more
wiley +1 more source
Chromosome X Open Reading Frame 38 (CXorf38) Is a Tumor Suppressor and Potential Prognostic Biomarker in Lung Adenocarcinoma: The First Characterization. [PDF]
Yan R +6 more
europepmc +1 more source
Upstream open reading frame-encoded MP31 disrupts the mitochondrial quality control process and inhibits tumorigenesis in glioblastoma. [PDF]
Huang N +9 more
europepmc +1 more source
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin +14 more
wiley +1 more source
Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides. [PDF]
Chen Y, Cao X, Loh KH, Slavoff SA.
europepmc +1 more source
Targeted Inactivation of a Tobacco Intron–containing Open Reading Frame Reveals a Novel Chloroplast-encoded Photosystem I–related Gene [PDF]
Stephanie Ruf, Hans Kössel, Ralph Bock
openalex +1 more source

