Results 21 to 30 of about 1,409,999 (372)
RNA elements in open reading frames of the bluetongue virus genome are essential for virus replication. [PDF]
PLoS ONE, 2014 Members of the Reoviridae family are non-enveloped multi-layered viruses with a double stranded RNA genome consisting of 9 to 12 genome segments. Bluetongue virus is the prototype orbivirus (family Reoviridae, genus Orbivirus), causing disease in ...
Femke Feenstra +3 more
doaj +1 more source
Association of chromosome 6 open reading frame 106 in different cancers
Frontiers in Bioscience-Landmark, 2021 Introduction: Cancer is the leading cause of death globally according to WHO in 2020. It is initiated by genetic mutations that occur due to numerous factors.
Emad Kutbi +3 more
doaj +1 more source
Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies. [PDF]
PLoS ONE, 2016 Duchenne and Becker muscular dystrophy severity depends upon the nature and location of the DMD gene lesion and generally correlates with the dystrophin open reading frame.
Zhi Yon Charles Toh +7 more
doaj +1 more source
Conserved Upstream Open Reading Frame Nascent Peptides that Control Translation.
Annual Review of Genetics, 2020 Cells utilize transcriptional and posttranscriptional mechanisms to alter gene expression in response to environmental cues. Gene-specific controls, including changing the translation of specific messenger RNAs (mRNAs), provide a rapid means to respond ...
T. Dever, I. Ivanov, M. Sachs
semanticscholar +1 more source
Mitochondrial-Derived Peptides in Diabetes and Its Complications
Frontiers in Endocrinology, 2022 The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in ...
Ying Wu +4 more
doaj +1 more source
AlterORF: a database of alternate open reading frames [PDF]
Nucleic Acids Research, 2007 AlterORF is a searchable database that contains information regarding alternate open reading frames (ORFs) for over 1.5 million genes in 481 prokaryotic genomes. The objective of the database is to provide a platform for improving genome annotation and to serve as an aid for the identification of prokaryotic genes that potentially encode proteins in ...
Pedroso, Inti +6 more
openaire +10 more sources
Selecting Open Reading Frames From DNA [PDF]
Genome Research, 2003 We describe a method to select DNA encoding functional open reading frames (ORFs) from noncoding DNA within the context of a specific vector. Phage display has been used as an example, but any system requiring DNA encoding protein fragments, for example, the yeast two-hybrid system, could be used.
Zacchi P. +4 more
openaire +4 more sources
An upstream open reading frame regulates LST1 expression during monocyte differentiation. [PDF]
PLoS ONE, 2014 The regulation of gene expression depends on the interplay of multiple factors at the transcriptional and translational level. Upstream open reading frames (uORFs) play an important role as translational repressors of main ORFs and their presence or ...
Christian Schiller +4 more
doaj +1 more source
Classification and function of small open reading frames [PDF]
Nature Reviews Molecular Cell Biology, 2017 Small open reading frames (smORFs) of 100 codons or fewer are usually - if arbitrarily - excluded from proteome annotations. Despite this, the genomes of many metazoans, including humans, contain millions of smORFs, some of which fulfil key physiological functions. Recently, the transcriptome of Drosophila melanogaster was shown to contain thousands of
Couso, Juan Pablo, Patraquim, Pedro
openaire +4 more sources
The random nature of genome architecture: predicting open reading frame distributions. [PDF]
PLoS ONE, 2009 BackgroundA better understanding of the size and abundance of open reading frames (ORFS) in whole genomes may shed light on the factors that control genome complexity.
Michael W McCoy +2 more
doaj +1 more source