Results 91 to 100 of about 627,878 (334)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Translational control of the human hemojuvelin via upstream open reading frames [PDF]
, 2012 Iron is an essential element for many biological reactions carried out by living systems. A tight regulation of systemic iron homeostasis is crucial to avoid the pathological conditions of iron deficiency or overload.
Barbosa, Cristina +2 more
core
Characterization of a second open reading frame in genome segment 10 of bluetongue virus [PDF]
, 2015 Viruses have often evolved overlapping reading frames in order to maximise their coding capacity. Until recently, the segmented double-stranded (ds) RNA genome of viruses of the Orbivirus genus was thought to be monocistronic but the identification of ...
Barry, Gerald +11 more
core +2 more sources
Target enrichment of long open reading frames and ultraconserved elements to link microevolution and macroevolution in non‐model organisms [PDF]
, 2022 Claudia Ortiz-Sepulveda +6 more
openalex +1 more source
Biochemical and Biophysical Research Communications, 2000 The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from exon 2.
Schluter, G. +2 more
openaire +3 more sources
C12orf5 (chromosome 12 open reading frame 5) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Review on C12orf5, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Simon, H +5 more
openaire +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
C11ORF30 (chromosome 11 open reading frame 30) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on C11ORF30 (chromosome 11 open reading frame 30), with data on DNA, on the protein encoded, and where the gene is implicated.
JL Huret, S Senon
openaire +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source