Results 11 to 20 of about 780,027 (226)

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

bioRxiv, 2023
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames.
Hofman DA, Ruiz-Orera J, Yannuzzi I, Murugesan R, Brown A, Clauser KR, Condurat AL, van Dinter JT, Engels SA, Goodale A, van der Lugt J, Abid T, Wang L, Zhou KN, Vogelzang J, Ligon KL, Phoenix TN, Roth JA, Root DE, Hubner N, Golub TR, Bandopadhayay P, van Heesch S, Prensner JR.   +23 more
europepmc   +2 more sources

Conserved upstream open reading frames in higher plants [PDF]

BMC Genomics, 2008
Background Upstream open reading frames (uORFs) can down-regulate the translation of the main open reading frame (mORF) through two broad mechanisms: ribosomal stalling and reducing reinitiation efficiency.
Schultz Carolyn J, Tran Michael K, Baumann Ute   +2 more
doaj   +4 more sources

Translational buffering by ribosome stalling in upstream open reading frames. [PDF]

PLoS Genetics, 2022
Upstream open reading frames (uORFs) are present in over half of all human mRNAs. uORFs can potently regulate the translation of downstream open reading frames through several mechanisms: siphoning away scanning ribosomes, regulating re-initiation, and ...
Ty A Bottorff, Heungwon Park, Adam P Geballe, Arvind Rasi Subramaniam   +3 more
doaj   +2 more sources

Pervasiveness of Microprotein Function Amongst Drosophila Small Open Reading Frames (SMORFS) [PDF]

Cells
Small Open Reading Frames (smORFs) of less than 100 codons remain mostly uncharacterised. About a thousand smORFs per genome encode peptides and microproteins about 70–80 aa long, often containing recognisable protein structures and markers of ...
Ana Isabel Platero, Jose Ignacio Pueyo, Sarah Anne Bishop, Emile Gerard Magny, Juan Pablo Couso   +4 more
doaj   +2 more sources

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames [PDF]

RNA Biology
Mutations in PKD1 coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. Regulation of PKD1 expression by factors located in the promoter and 3´
Lei Chen, Xia Gao, Xiangshen Liu, Ye Zhu, Dong Wang   +4 more
doaj   +2 more sources

Upstream open reading frames may contain hundreds of novel human exons. [PDF]

PLoS Computational Biology
Several recent studies have presented evidence that the human gene catalogue should be expanded to include thousands of short open reading frames (ORFs) appearing upstream or downstream of existing protein-coding genes, each of which might create an ...
Hyun Joo Ji, Steven L Salzberg
doaj   +2 more sources

Computational discovery and annotation of conserved small open reading frames in fungal genomes

BMC Bioinformatics, 2019
Background Small open reading frames (smORF/sORFs) that encode short protein sequences are often overlooked during the standard gene prediction process thus leading to many sORFs being left undiscovered and/or misannotated.
Shuhaila Mat-Sharani, Mohd Firdaus-Raih
doaj   +2 more sources

Short Open Reading Frames and Their Encoded Peptides [PDF]

PROTEOMICS, 2018
In this article, the following sentences and reference were erroneously published: “In their technical brief, Khitun and Slavoff describe their workflow to detect and validate non-annotated proteins with non-AUG start sites.
J. Rothnagel, G. Menschaert
semanticscholar   +6 more sources

Mutational constraint analysis workflow for overlapping short open reading frames and genomic neighbors [PDF]

BMC Genomics
Understanding the dark genome is a priority task following the complete sequencing of the human genome. Short open reading frames (sORFs) are a group of largely unexplored elements of the dark genome with the potential for being translated into ...
Martin Danner, Matthias Begemann, Florian Kraft, Miriam Elbracht, Ingo Kurth, Jeremias Krause   +5 more
doaj   +2 more sources

Small open reading frames and cellular stress responses.

Molecular Omics, 2019
Small open reading frames (smORFs) encoding polypeptides of less than 100 amino acids in eukaryotes (50 amino acids in prokaryotes) were historically excluded from genome annotation.
Alexandra Khitun, Travis J Ness, Sarah A. Slavoff   +2 more
semanticscholar   +4 more sources