Results 11 to 20 of about 627,878 (334)

Conserved upstream open reading frames in higher plants [PDF]

BMC Genomics, 2008
Background Upstream open reading frames (uORFs) can down-regulate the translation of the main open reading frame (mORF) through two broad mechanisms: ribosomal stalling and reducing reinitiation efficiency.
Schultz Carolyn J, Tran Michael K, Baumann Ute   +2 more
doaj   +4 more sources

Upstream open reading frames may contain hundreds of novel human exons. [PDF]

PLoS Computational Biology
Several recent studies have presented evidence that the human gene catalogue should be expanded to include thousands of short open reading frames (ORFs) appearing upstream or downstream of existing protein-coding genes, each of which might create an ...
Hyun Joo Ji, Steven L Salzberg
doaj   +2 more sources

Mutational constraint analysis workflow for overlapping short open reading frames and genomic neighbors [PDF]

BMC Genomics
Understanding the dark genome is a priority task following the complete sequencing of the human genome. Short open reading frames (sORFs) are a group of largely unexplored elements of the dark genome with the potential for being translated into ...
Martin Danner, Matthias Begemann, Florian Kraft, Miriam Elbracht, Ingo Kurth, Jeremias Krause   +5 more
doaj   +2 more sources

Upstream open reading frames buffer translational variability during Drosophila evolution and development [PDF]

eLife
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown.
Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu   +8 more
doaj   +2 more sources

Short internal open reading frames repress the translation of N-terminally truncated proteoforms [PDF]

EMBO Reports
Internal translation initiation sites, as revealed by ribosome profiling experiments can potentially drive the translation of many N-terminally truncated proteoforms.
Raphael Fettig, Zita Gonda, Niklas Walter, Paul Sallmann, Christiane Thanisch, Markus Winter, Susanne Bauer, Lei Zhang, Greta Linden, Margarethe Litfin, Marina Khamanaeva, Sarah Storm, Christina Münzing, Christelle Etard, Olivier Armant, Olalla Vázquez, Olivier Kassel   +16 more
doaj   +2 more sources

Multi-integrated approach for unraveling small open reading frames potentially associated with secondary metabolism in <i>Streptomyces</i>. [PDF]

mSystems, 2023
Fan S-M, Li Z-Q, Zhang S-Z, Chen L-Y, Wei X-Y, Liang J, Zhao X-Q, Su C.   +7 more
europepmc   +2 more sources

Open Reading Frame Phylogenetic Analysis on the Cloud [PDF]

International Journal of Genomics, 2013
Phylogenetic analysis has become essential in researching the evolutionary relationships between viruses. These relationships are depicted on phylogenetic trees, in which viruses are grouped based on sequence similarity.
Che-Lun Hung, Chun-Yuan Lin
doaj   +3 more sources

Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes. [PDF]

Viruses
Arhab Y, Pestova TV, Hellen CUT.
europepmc   +2 more sources

Identification of proteoforms of short open reading frame-encoded peptides in Blautia producta under different cultivation conditions

Microbiology Spectrum, 2023
Short open reading frames (sORF) have the potential to encode small proteins, sORF-encoded peptides (SEP), which are less than or equal to 100 amino acids in length.
Jerome Genth, Kathrin Schäfer, Liam Cassidy, Simon Graspeuntner, Jan Rupp, Andreas Tholey   +5 more
doaj   +1 more source

Non-conventional peptides in plants: From gene regulation to crop improvement

Crop Journal, 2023
Conventional peptides (CPs) and non-conventional peptides (NCPs) are generated from small open reading frames, but most CPs are derived from large precursors. NCPs, which are derived from sequences other than conventional open reading frames or annotated
Huan Chen, Jingjuan Yu, Wen-Xue Li
doaj   +1 more source