Results 121 to 130 of about 63,196 (314)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Study on Deformation of New Tunnels Overcrossing Existing Tunnels Underneath Operating Railways

Buildings
With the increasing utilization of urban underground space, new tunnels frequently intersect with existing tunnels and operational railways. However, sometimes the excavation and unloading of new tunnels can cause deformation of adjacent existing tunnels
Can Xie, Yuhang Qu, Haiyan Lu, Shuguang Song   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of CT and VT Connection Point on Distance Protection of Transmission Lines with FACTS Devices

Iranian Journal of Electrical and Electronic Engineering, 2006
This paper presents the effects of instrument transformers connection points on the measured impedance by distance relays in the presence of Flexible Alternating Current Transmission System (FACTS) devices with series connected branch.
H. Shateri, S. Jamali
doaj  

A METHOD FOR ASSESSING THE OPERATIONAL RELIABILITY OF WELDED CONNECTIONS FROM 09G2S STEEL WORKING IN ENVIRONMENTS CAUSING CORROSIVE CRACKING

, 2021
I. A. Trishkina, E. I. Storozheva, A. Yu. Feitullaev, Р Е Новиков   +3 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Staged Kawashima operation with cavopulmonary connection [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2012
Sathe, Yogesh, Chidambaram, Shanthi, Manohar, Krishna, Cherian, Kotturathu Mammen   +3 more
openaire   +2 more sources

Intelligence and Creativity: Epistemological Connections and Operational Implications in Educational Contexts

, 2020
Carla Luciane Blum Vestena, Juliana Berg, Weslley Kozlik Silva, Cristina Costa-Lobo   +3 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Health assessment of the electrical contact-line connections in view of the operational traction load pattern of the electric rolling stock

, 2020
Ivan Ignatenko, Sergey Vlasenko
openalex   +1 more source