Results 211 to 220 of about 602,372 (317)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Coliform Load and Antimicrobial Resistance in Ghana's Seafood Processing Effluent (2021-2024): Evidence of Operational Improvement and Persistent AMR Risk. [PDF]

Life (Basel)
Wallace-Dickson EW, Agyarkwa MA, Klutse NAB, Nerquaye-Tetteh EN, Abubakari A, Amoah S, Kudjawu J, Azaglo GS, Batong MF, Ade J, Okyere IJ, Osei MM, Quansah KE, Obeng Bekoe EM, Hedidor GK, Nair D, Terry RF, Opintan JA.   +17 more
europepmc   +1 more source

Detection of malaria in relation to fever and grade of malnutrition among malnourished children in Ethiopia [PDF]

, 2011
Ayada, L., Harries, A.., Hinderaker, S.G., Jima, D., Keiluhu, A., Khogali, M., Tayler-Smith, K., Van den Brande, K., Zachariah, R.   +8 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Integrating mobile laboratories into global health security: advancing collaboration through GOARN-DiSC. [PDF]

BMJ Glob Health
Storozhenko O, Albarraq A, Al-Sanouri T, Antonation K, Corbett CR, Dacheux L, Duraffour S, Flevaud L, Gala JL, Haby MM, Newman EN, Raftery P, Salio F, Torda P, Weiss S.   +14 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Reaching the last mile with ivermectin mass drug administration against onchocerciasis: The case of Kwanware-Ottou persistent transmission focus in the Wenchi health district of Ghana. [PDF]

PLoS Negl Trop Dis
Nditanchou R, Oluwole AS, Basnet S, Chailloux A, Saare J, Agyemang D, King SA, Osei-Atweneboana MY, Selby R, Opare J, Hamill L, Fodjo JNS, Verhoeven V, Schmidt E, Colebunders R.   +14 more
europepmc   +1 more source

Parenting Early Intervention Programme Evaluation (Research report DFE-RR121(a)) [PDF]

, 2011
Band, Sue, Barlow, Jane, Conlon, Gavan, Cullen, Mairi Ann, Cullen, Stephen, Davis, Hilton, Evans, Ray, Lindsay, Geoff, Strand, Steve   +8 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Cost analysis of probiotic/synbiotic supplementation in infants in rural Kenya: a study from the PROSYNK trial. [PDF]

BMJ Paediatr Open
McCallum B, Iwaret Otiti M, Achieng F, Allen S, Worrall E.   +4 more
europepmc   +1 more source