Results 241 to 250 of about 78,638 (313)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Antarctic science operations must account for climate change and extreme environmental events. [PDF]

Commun Earth Environ
Siegert M, Bracegirdle TJ, Convey P, Hendry K, Holmes C, Hughes KA.   +5 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Correction to "Guiding AlphaFold predictions with experimental knowledge to inform dynamics and interactions with VAIRO". [PDF]

Protein Sci
europepmc   +1 more source

Governance of antimicrobial resistance in Central Africa (2015-2025): a systematic review of policies, One Health coordination and funding. [PDF]

JAC Antimicrob Resist
Kamsu GT, Djuikoue IC, Thumamo Pokam BD, Seugnou Nana CD, Ngandjui Yonga C, Mboupaing MG, Marehin MS, Makaya Danguil Nieko NP, Sanou Kue F, Banze Mewehu T, Tseuko D, Hironi S, Mboliyou MT, Gatse Bouya RA, Apalata TR, Antoine-Moussiaux N.   +15 more
europepmc   +1 more source

Multilevel Determinants of Tuberculosis Treatment Interruption in Rural South Africa: Insights from Primary Healthcare Nurses. [PDF]

Int J Environ Res Public Health
Tsibiyane M, Faye LM, Ndayi K, Sineke N, Tyeshani L, Faleni M.   +5 more
europepmc   +1 more source

Comparison of an integrated versus stand-alone approach to post-validation surveillance for lymphatic filariasis in Niue: a micro-costing study, 2025. [PDF]

J Glob Health
Craig AT, Lawford HL, Mokoia G, Tatui P, Nicolas M, Murphy A, Marquardt T, Nghiem SH, Stanciole AE, Lau CL.   +9 more
europepmc   +1 more source

High levels of unfavourable treatment outcomes in children with drug-sensitive TB in Sierra Leone. [PDF]

Public Health Action
Sesay N, Kamara IF, Kumar AMV, Thekkur P, Alwani AA, Fofanah BD, Kamara ARY, Bah A, Farma-Grant L, Sesay MA, Lahai WK, Koroma JA, Tengbe SM, Kanu F, Ameh G, Kanneh SM, Zachariah R, Mahmoud M.   +17 more
europepmc   +1 more source

Measles re-emergence in Mexico: essential public health functions under strain. [PDF]

Lancet Reg Health Am
Serván-Mori E, Triana-Ballina A, Meneses-Navarro S.   +2 more
europepmc   +1 more source

Combating dengue using male <i>Wolbachia-</i>infected mosquitoes-lessons from Singapore's experience. [PDF]

Lancet Reg Health West Pac
Lim JT, Lee VJ, Tan CH, Chong CS, Vasquez K, Ng LC.   +5 more
europepmc   +1 more source