Results 111 to 120 of about 260,764 (294)

Sequence homolog-based molecular engineering for shifting the enzymatic pH optimum

Synthetic and Systems Biotechnology, 2016
Cell-free synthetic biology system organizes multiple enzymes (parts) from different sources to implement unnatural catalytic functions. Highly adaption between the catalytic parts is crucial for building up efficient artificial biosynthetic systems ...
Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang   +7 more
doaj   +1 more source

Global stability of reaction-diffusion equations with fractional Laplacian operator and applications in biology

, 2022

openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Potential application of thermography (IRT) in animal production and for animal welfare. A case report of working dogs

Annali dell'Istituto Superiore di Sanità, 2014
INTRODUCTION. The authors describe the thermography technique in animal production and in veterinary medicine applications. The thermographic technique lends itself to countless applications in biology, thanks to its characteristics of versatility, lack ...
Veronica Redaelli, Nicola Ludwig, Leonardo Nanni Costa, Lorenzo Crosta, Jacopo Riva, Fabio Luzi   +5 more
doaj   +1 more source

Degenerate Diffusion Operators Arising in Population Biology [PDF]

, 2013
Charles L. Epstein, Rafe Mazzeo
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Harnack Inequalities and Heat Kernel Estimates for Degenerate Diffusion Operators Arising in Population Biology [PDF]

, 2016
Charles L. Epstein, Rafe Mazzeo
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Kinetic equation for a gas with attractive forces as a functional equation

Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2009
Diffusion problems studied in the time scale comparable with time of particles collision lead to kinetic equations which for step-wise potentials are functional equations in the velocity space.
Ryszard Wojnar
doaj