Results 111 to 120 of about 3,251,963 (366)

Reliable extrapolation of deep neural operators informed by physics or sparse observations

, 2023
Min Zhu, Handi Zhang, Anran Jiao, George Em Karniadakis, Lu Lu   +4 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aczel–Alsina Power Aggregation Operators for Complex Picture Fuzzy (CPF) Sets with Application in CPF Multi-Attribute Decision Making [PDF]

, 2023
Zeeshan Ali, Tahir Mahmood, Miin‐Shen Yang   +2 more
openalex   +1 more source

On Integral Operators with Operator-Valued Kernels [PDF]

Journal of Inequalities and Applications, 2010
Here Lq-Lp boundedness of integral operator with operator-valued kernels is studied and the main result is applied to convolution operators. Using these results Besov space regularity for Fourier multiplier operator is established.
openaire   +4 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Pythagorean fuzzy interaction power Bonferroni mean aggregation operators in multiple attribute decision making

International Journal of Intelligent Systems, 2019
The power Bonferroni mean (PBM) operator can relieve the influence of unreasonable aggregation values and also capture the interrelationship among the input arguments, which is an important generalization of power average operator and Bonferroni mean ...
Lei Wang, N. Li
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Fundamental Properties of Interval‐Valued Pythagorean Fuzzy Aggregation Operators

International Journal of Intelligent Systems, 2016
In this paper, we investigate the multiple attribute group decision making (MAGDM) problems with interval‐valued Pythagorean fuzzy sets (IVPFSs). First, the concept, operational laws, score function, and accuracy function of IVPFSs are defined.
Xindong Peng, Yong Yang
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On nonlocal quasilinear equations and their local limits

, 2016
We introduce a new class of quasilinear nonlocal operators and study equations involving these operators. The operators are degenerate elliptic and may have arbitrary growth in the gradient.
Chasseigne, Emmanuel, Jakobsen, Espen
core   +1 more source