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Role of osteoprotegerin (OPG) in cancer

Clinical Science, 2006
OPG (osteoprotegerin), a secreted member of the TNF (tumour necrosis factor) receptor superfamily, has a variety of biological functions which include the regulation of bone turnover. OPG is a potent inhibitor of osteoclastic bone resorption and has been investigated as a potential therapeutic for the treatment of both osteoporosis and tumour-induced ...
Holen, I, Shipman, C
openaire   +3 more sources

OPGs and pandemic legacy [PDF]

British Dental Journal, 2021
A, Regan, T, Walker
openaire   +2 more sources

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

Pharmaceutics, 2020
Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of whether OPG expression responds to ...
Adhyatmika Adhyatmika, Leonie Beljaars, Kurnia S. S. Putri, Habibie Habibie, Carian E. Boorsma, Catharina Reker-Smit, Theerut Luangmonkong, Burak Guney, Axel Haak, Keri A. Mangnus, Eduard Post, Klaas Poelstra, Kim Ravnskjaer, Peter Olinga, Barbro N. Melgert   +14 more
doaj   +1 more source

Foreign body in the tongue as a result of accidental gunshot from hunting rifle

Journal of Education, Health and Sport, 2019
Gunshots are one of the many causes of urgent admission of patients due to necessity of removing foreign bodies and bleeding control. A 63 y.o. patient was referred to the Department of Oral Surgery due to an accidental gunshot, which occurred in early ...
Monika Ratajek-Gruda, Olga Strzelczyk-Sikorska, Anna Janas-Naze   +2 more
doaj   +1 more source

Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling

Stem Cell Research & Therapy, 2021
Introduction Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.
Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li, De-Zhi Tang   +5 more
doaj   +1 more source

Delayed denervation-induced muscle atrophy in Opg knockout mice

Frontiers in Physiology, 2023
Recent evidence has shown a crucial role for the osteoprotegerin/receptor activator of nuclear factor κ-B ligand/RANK (OPG/RANKL/RANK) signaling axis not only in bone but also in muscle tissue; however, there is still a lack of understanding of its ...
Mingming Zhang, Mingming Zhang, Ming Chen, Ming Chen, Yi Li, Yi Li, Man Rao, Man Rao, Duanyang Wang, Zhongqi Wang, Zhongqi Wang, Licheng Zhang, Licheng Zhang, Pengbin Yin, Pengbin Yin, Peifu Tang, Peifu Tang   +16 more
doaj   +1 more source

Osteoprotegerin: Relationship to Breast Cancer Risk and Prognosis

Frontiers in Oncology, 2020
Osteoprotegerin (OPG) is a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily (TNFRSF11B), that was first characterized and named for its protective role in bone remodeling.
Dirk Geerts, Christina Chopra, Linda Connelly   +2 more
doaj   +1 more source

Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion. [PDF]

PLoS ONE, 2016
Osteoprotegerin (OPG), a decoy receptor for receptor activator of NF-κB ligand (RANKL), antagonizes RANKL's osteoclastogenic function in bone. We previously demonstrated that systemic administration of lipopolysaccharide (LPS) to mice elevates OPG levels
Yukiko Kuroda, Kenta Maruyama, Hideki Fujii, Isamu Sugawara, Shigeru B H Ko, Hisataka Yasuda, Hidenori Matsui, Koichi Matsuo   +7 more
doaj   +1 more source

From the Church, With the Church, and For the Church: Another Look at the Significance of Parachurch for Church Growth

Veritas: Jurnal Teologi dan Pelayanan, 2023
This article discusses parachurch (hereinafter referred to as the Organisasi Pendamping Gereja / OPG). According to Jerry White, a parachurch is all forms of spiritual ministry whose organizational structure is not under the control of the church ...
Tommy Indarto
doaj   +1 more source

RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp

Scientific Reports, 2021
Bone-resorbing osteoclasts are regulated by the relative ratio of the differentiation factor, receptor activator NF-kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG).
Daisuke Nishida, Atsushi Arai, Lijuan Zhao, Mengyu Yang, Yuko Nakamichi, Kanji Horibe, Akihiro Hosoya, Yasuhiro Kobayashi, Nobuyuki Udagawa, Toshihide Mizoguchi   +9 more
doaj   +1 more source