Results 31 to 40 of about 77,539 (257)

Biochemical characterization of a disease-causing human osteoprotegerin variant

Scientific Reports, 2022
Recently, a human mutation of OPG was identified to be associated with familial forms of osteoarthritis. This missense mutation (c.1205A =  > T; p.Stop402Leu) occurs on the stop codon of OPG, which results in a 19-residue appendage to the C-terminus (OPG+
Yin Luo, Miaomiao Li, Ding Xu
doaj   +1 more source

Novel Two-dimensional Carbon Allotrope with Strong Electronic Anisotropy

, 2013
Two novel two-dimensional carbon allotropes comprised of octagons and pentagons are proposed based on the first-principles calculations. The two carbon allotropes, named OPG-L and OPG-Z, are found to have distinct properties. OPG-L is metallic, while OPG-
Feng, Ji, Jiang, Hua, Su, Cong
core   +1 more source

Gate-controlled Guiding of Electrons in Graphene

, 2010
Ballistic semiconductor structures have allowed the realization of optics-like phenomena in electronics, including magnetic focusing and lensing. An extension that appears unique to graphene is to use both n and p carrier types to create electronic ...
A Shytov, AF Young, AH Castro Neto, AK Geim, B Huard, B Özyilmaz, C. M. Marcus, CEP Villegas, CH Park, CWJ Beenakker, CWJ Beenakker, D Dragoman, DW Wilson, E Rossi, EG Mishchenko, EP Cesar, F Guinea, F-M Zhang, H van Houten, J. R. Williams, JR Williams, LM Zhang, M. S. Lundstrom, MI Katsnelson, N Levy, N Stander, RR Hartmann, T Low, T Low, Tony Low, U Sivan, VV Cheianov, VV Cheianov, Y He   +33 more
core   +1 more source

Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]

, 2010
Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja, Guenther, Axel, Lau, Esther, Liu, Dawei, Wang, Liyun, You, Lidan   +5 more
core   +2 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

Pathophysiological roles of osteoprotegerin (OPG)

European Journal of Cell Biology, 2009
Osteoprotegerin (OPG) is a secreted glycoprotein central to bone turnover via its role as a decoy receptor for the receptor activator of nuclear factor kappaB ligand (RANKL) and has traditionally been linked to a number of bone-related diseases. However, there is additional evidence that OPG can promote cell survival by inhibiting TNF-related apoptosis-
Penny, Reid, Ingunn, Holen
openaire   +2 more sources

A Potential Novel Molecular Interaction in Bronchiolitis Obliterans Syndrome in Lung Transplantation Patients: The Role of SERPINA3 and Osteoprotegerin. [PDF]

FASEB J
Serum SERPINA3 levels were higher in BOS compared to non‐BOS patients. OPG and SERPINA3 positive cells colocalized with tryptase positive mast cells in airways from BOS lung tissue. OPG and SERPINA3 staining positively correlated in partially and completely obstructed airways.
Liu Y, van der Ploeg EA, Borghuis T, Menz RI, Timens W, Vonk JM, Melgert BN, Gan CT, Burgess JK.   +8 more
europepmc   +2 more sources

Optical parametric generator based on orientation-patterned gallium phosphide [PDF]

, 2017
We report the first pulsed optical parametric generator based on Orientation-patterned Gallium Phosphide. The output is tunable from 1721-1850 nm (signal) and 2504-2787 nm (idler), providing a total output power of 18 mW.Peer ReviewedPostprint (author's ...
Chaitanya Kumar, S., Ebrahim-Zadeh, Majid, Schunemann, P. G., Wei, Junxiong, Ye, Hanyu   +4 more
core   +1 more source

The unbearable lightness of bone marrow homeostasis [PDF]

, 2015
The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS, Douni E., MARCHETTI, Luigi, SABBIETI, Maria Giovanna   +3 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source