Results 31 to 40 of about 52,735 (283)
Biochemical characterization of a disease-causing human osteoprotegerin variant
Scientific Reports, 2022 Recently, a human mutation of OPG was identified to be associated with familial forms of osteoarthritis. This missense mutation (c.1205A = > T; p.Stop402Leu) occurs on the stop codon of OPG, which results in a 19-residue appendage to the C-terminus (OPG+
Yin Luo, Miaomiao Li, Ding Xu
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DataSheet2_Delayed denervation-induced muscle atrophy in Opg knockout mice.PDF
, 2023 Recent evidence has shown a crucial role for the osteoprotegerin/receptor activator of nuclear factor κ-B ligand/RANK (OPG/RANKL/RANK) signaling axis not only in bone but also in muscle tissue; however, there is still a lack of understanding of its ...
Licheng Zhang (590322) +8 more
core +1 more source
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Maxillofacial injuries are common and they occur in a variety of situations. All patients who undergo maxillofacial or head trauma, are presumed to sustain cervical spine injuries. Identification of cervical spine injuries is essential in management of trauma, because a missed injury can result in a catastrophic spinal cord injury. Advanced Trauma Life
Kedarnath N.S., Mamatha N.S., Shruthi R.
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Mice lacking OPG show altered glucose metabolism.
, 2016 (A) Fasting blood glucose levels (f.BGL) in control (Opg+/±, n = 11, 8) and OPG knockout (Opg-/-, n = 14, 9) mice 16 hr after injection of PBS or LPS. Shown are means ± SEM. ***P < 0.005.
Hisataka Yasuda (845001) +7 more
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Pathophysiological roles of osteoprotegerin (OPG)
European Journal of Cell Biology, 2009 Osteoprotegerin (OPG) is a secreted glycoprotein central to bone turnover via its role as a decoy receptor for the receptor activator of nuclear factor kappaB ligand (RANKL) and has traditionally been linked to a number of bone-related diseases. However, there is additional evidence that OPG can promote cell survival by inhibiting TNF-related apoptosis-
Penny, Reid, Ingunn, Holen
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Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
Advanced Science, EarlyView.Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne +15 more
wiley +1 more source
Open MedicineObesity has been recognized as a global epidemic and public health crisis. The prevalence of obesity has tripled since 1975, especially in the elderly population.
Liu Jinling +8 more
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Drug Design, Development and Therapy, 2020 Ye Zhao, 1, 2 Hui-Ling Wang, 1 Tong-Tong Li, 1 Fei Yang, 1 Chi-Meng Tzeng 1 1School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211800, People’s Republic of China; 2Jiangsu Synergetic Innovation Center for Advanced Bio ...
Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM
doaj
Frontiers in Cell and Developmental Biology, 2020 Osteoprotegerin (OPG) is involved in various biological processes, including bone remodeling, vascular calcification and pancreatic β-cell function. Although some clinical studies have shown an increase in serum OPG level during pregnancy, the role of ...
Binbin Huang +20 more
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