Results 61 to 70 of about 46,164 (349)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Effectiveness of autologous serum eye drops in the treatment of corneoconjunctival burns

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2019
Background: ocular burns are a health problem since they have a relevant place in the ophthalmological practice.Objective: to assess the effectiveness of 50 % autologous serum eye drops combined with the conventional treatment of corneoconjunctival burns
Yanier Serrano-García, Alena de los Ángeles Vejerano-Duany, María Del Carmen González-Fernández, Leonor Gallardo-Roca, Taimi Miranda-Vergara   +4 more
doaj  

Pharmacokinetics of Azithromycin, Levofloxacin, and Ofloxacin in Rabbit Extraocular Tissues After Ophthalmic Administration

Ophthalmology and Therapy, 2019
Introduction Azithromycin demonstrates high tissue distribution and prolonged elimination half-life. In this study, we monitored the pharmacokinetics of a single ophthalmic administration of 1% azithromycin ophthalmic solution containing polycarbophil in
Tatsuya Sakai, Keisuke Shinno, Masaaki Kurata, Akio Kawamura   +3 more
doaj   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

The chemotactic properties of various topical brimonidine tartrate ophthalmic preparations

BMC Pharmacology and Toxicology, 2020
Background The study aimed to evaluate and compare the leukocyte chemotactic activities of various brimonidine tartrate (BT) eye drop formulations. Methods A 96-well dot-blot platet using a Boyden-style well was used to study the chemotactic effects of ...
Ruiz Simonato Alonso, Helena Parente Solari, Eduardo de França Damasceno, Miguel Noel Nascentes Burnier, Marcelo Palis Ventura   +4 more
doaj   +1 more source

Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi. [PDF]

, 2020
Recent increases in the prevalence and severity of wildfires in some regions have resulted in an increased frequency of veterinary burn patients. Few studies exist regarding diagnostics and management of burn wounds in veterinary patients and current ...
Epstein, Steven E, Gunther-Harrington, Catherine T, Li, Ronald HL, Sharpe, Ashley N, Stern, Joshua A   +4 more
core  

Multidimensional en-face OCT imaging of the retina. [PDF]

, 2009
Fast T-scanning (transverse scanning, en-face) was used to build B-scan or C-scan optical coherence tomography (OCT) images of the retina. Several unique signature patterns of en-face (coronal) are reviewed in conjunction with associated confocal images ...
Adrian G. Podoleanu, Cucu, de Boer, George M. Dobre, Gh, Gh, Gh, Gh, Gh, Gh, Gh, Gh, Hitzenberger, Hong, Huber, Jiao, John Rogers, Justin Pedro, Leitgeb, Lim, Mark Hathaway, Masters, Merino, Patricia Garcia, Philippe Laissue, Pircher, Pircher, Pircher, Pircher, Richard B. Rosen, Rosa, Tuohy, Van Velthoven, Wojtkowski, Yasuno   +34 more
core   +1 more source

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Microbiological Analysis of Ophthalmic Solutions

RADS Journal of Biological Research & Applied Science, 2015
Microbial corneal contamination is the most genuine confusion of contact lens wear. A defiled contact lens arrangement and embellishments can go about as a supply for microorganisms that could conceivably agree contact lens wear and prompt sight ...
Sana Siraj Khan, Amna Shafiq, Syeda Ghufrana Nadeem   +2 more
doaj  

Tear Film and Keratitis in Space: Fluid Dynamics and Nanomedicine Strategies for Ocular Protection in Microgravity

Pharmaceutics
Spaceflight-associated dry eye syndrome (SADES) has been reported among astronauts during both International Space Station (ISS) and Space Transportation System (STS) missions.
Ryung Lee, Rahul Kumar, Jainam Shah, Joshua Ong, Ethan Waisberg, Alireza Tavakkoli   +5 more
doaj   +1 more source