Results 141 to 150 of about 574,925 (310)

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid‐Related Loci as the Main Driver of Opioid Use Disorder

Genetic Epidemiology
ABSTRACTPersistent opioid use after surgery is a common morbidity outcome associated with subsequent opioid use disorder, overdose, and death. While phenotypic associations have been described, genetic associations remain unidentified. Here, we conducted the largest genetic study of persistent opioid use after surgery, comprising ~40,000 non‐Hispanic ...
Aubrey C. Annis, Vidhya Gunaseelan, Albert V. Smith, Gonçalo R. Abecasis, Daniel B. Larach, Matthew Zawistowski, Stephan G. Frangakis, Chad M. Brummett   +7 more
openaire   +2 more sources

Infant Death due to Cannabis Ingestion

Drug Testing and Analysis, EarlyView.
ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Oriana Cuman, Anna Pagliaro, Fabio Mattiazzi, Cristina Basso, Maddalena Galeazzi   +9 more
wiley   +1 more source

A Comprehensive Review on Capillary Electrophoresis–Mass Spectrometry in Advancing Biomolecular Research

ELECTROPHORESIS, EarlyView.
ABSTRACT This review provides an in‐depth exploration of capillary electrophoresis–mass spectrometry (CE–MS) in biomolecular research from 2020 to 2024. CE–MS emerges as a versatile and powerful tool due to its numerous advantages, facilitating the analysis of various biomolecules, including proteins, peptides, oligonucleotides, and other metabolites ...
Laura Pont, María Vergara‐Barberán, Enrique Javier Carrasco‐Correa   +2 more
wiley   +1 more source

A Renal Impairment Subgroup Analysis of the Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy

Journal of Pain Research, 2020
Lynn R Webster,1 Martin E Hale,2 Tadaaki Yamada,3 James E Wild4 1PRA Health Sciences, Salt Lake City, UT, USA; 2Gold Coast Research LLC, Plantation, FL, USA; 3Shionogi, Inc., Florham Park, NJ, USA; 4Upstate Clinical Research Associates, Williamsville, NY,
Webster LR, Hale ME, Yamada T, Wild JE
doaj  

Cognitive behaviour therapy as an evidence-based intervention for opioid use disorder: a systematic review

Journal of the Pakistan Medical Association
Objective: To explore the effectiveness of cognitive behaviour therapy as an evidence-based intervention for patients with opioid use disorder and to estimate the effect of cognitive behaviour therapy in mental health care settings.
Mafia Shahzadi, Khalid Mahmood Bhati
doaj   +1 more source

Sojae Semen Praeparatum Fermented by Rhizopus chinensis and Bacillus sp. DU‐106 Alleviates Loperamide‐Induced Constipation in Rats via Regulating Calcium Signaling Pathways and the Gut Microbiota

Food Frontiers, EarlyView.
To investigate the effects of different processing methods of Sojae Semen Praeparartum (SSP) on constipation, we prepared SSP through fermentation using Rhizopus chinensis and Bacillus sp. DU‐106 as starter cultures, and examined its laxative effects and mechanisms in loperamide‐induced constipated Sprague‐Dawley (SD) rats.
Rong xiang Guo, Chao fan Zhao, Yan li Li, Yun xi Zhang, Fu Yao Luo, Yi hang Sun, Ya fei Wang, Jun Yuan Huang, Bing Du, Pan Li   +9 more
wiley   +1 more source

Hidden Costs of Ban the Box Laws: Unraveling the Effects on Drug‐Related Deaths

Health Economics, EarlyView.
ABSTRACT Ban the Box (BTB) laws delay criminal background checks until the later stages of the hiring process. This study provides new evidence that BTB laws that apply to both private and public employers have negative spillover effects beyond labor market outcomes.
Oleksandra Cheipesh
wiley   +1 more source

Post‐Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study

Head &Neck, EarlyView.
ABSTRACT Background This study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids. Methods Patients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010–2024). Cohorts were divided based on opioid prescriptions on the day of surgery.
Oluwatobiloba Ayo‐Ajibola, Milan P. Fehrenbach, Asher C. Park, Jonathan D. West, Daniel I. Kwon   +4 more
wiley   +1 more source

“My Addiction Doesn’t Define Me”—Experiences of Stigma among Mothers with Opioid Use Disorder

Pharmacoepidemiology
Opioid use in women has increased by 300% since 1999, and opioid use disorder among pregnant women has quadrupled. The stigma of substance use disorder is a significant barrier to treatment, especially among women.
Christine Bakos-Block, Andrea Yatsco, A. Sarah Cohen, Francine Vega, Tiffany Champagne-Langabeer   +4 more
doaj   +1 more source

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source