Results 91 to 100 of about 495,046 (363)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Patient Perspectives of Disease Activity, Medications and Substance Use in People with Fibromyalgia

Open Access Rheumatology: Research and Reviews, 2022
Thomas Khoo,1 Catherine L Hill,1– 3 Elizabeth Hoon,4,5 Samuel Whittle1 1Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia; 2Rheumatology Unit, The Royal Adelaide Hospital, Adelaide, South Australia, Australia ...
Khoo T, Hill CL, Hoon E, Whittle S
doaj  

“I never realized how hard recovery is.” A quasi‐experimental evaluation of a youth participatory action research project for opioid prevention

American Journal of Community Psychology, EarlyView.
Abstract Youth participatory action research (YPAR) has been effectively used for substance use prevention. Yet, YPAR has not been evaluated for opioids, which negatively impact individuals and communities across the United States. The current study evaluated an opioid‐focused YPAR project.
Elizabeth H. Weybright, Katherine Hampilos, Alison J. White, Cassandra Grinstead, Jennifer Fees, Melanie Greer, Erica L. Doering, Laurie M. Graham   +7 more
wiley   +1 more source

Clinical effectiveness and treatment satisfaction between two triple‐therapy regimens in treating neuropathic pain: A real‐world data

Ibrain, EarlyView., 2023
This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju, Samyuktha Villavan, Saranya Ravi, Roja Murugesan, Panneerselvam Theivendren, Vennila Jaganathan, Redlin Jani Rajan, Krupanidhi Karunanithi   +7 more
wiley   +1 more source

Monitoring and Improving Naltrexone Adherence in Patients with Substance Use Disorder

Patient Preference and Adherence, 2021
Virginia Perez-Macia,1,2 Mireia Martinez- Cortes,3 Jesus Mesones,1,2 Manuel Segura-Trepichio,4 Lorena Garcia-Fernandez3,5 1Vinalopó University Hospital, Elche, Spain; 2Psychology and Psychiatry Department, Catholic University of Murcia, Murcia ...
Perez-Macia V, Martinez- Cortes M, Mesones J, Segura-Trepichio M, Garcia-Fernandez L   +4 more
doaj  

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

Naloxone distribution programs in the emergency department: A scoping review of the literature

Journal of the American College of Emergency Physicians Open
This scoping review summarized the literature regarding naloxone distribution from emergency departments (EDs) without a prescription. Our intention was to examine various naloxone distribution programs, their methodologies, and the level of ...
Mohan K. Sindhwani, Adam Friedman, Maureen O'Donnell, Donald Stader, Scott G. Weiner   +4 more
doaj   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

eLife, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Kathryn E Livingston, Jacob P Mahoney, Aashish Manglik, Roger K Sunahara, John R Traynor   +4 more
doaj   +1 more source

A Prospective Evaluation of Opioid Utilization After Upper-Extremity Surgical Procedures: Identifying Consumption Patterns and Determining Prescribing Guidelines. [PDF]

, 2016
BACKGROUND: Although adequate management of postoperative pain with oral analgesics is an important aspect of surgical procedures, inadvertent overprescribing can lead to excess availability of opioids in the community for potential diversion.
Abboudi, Jack, Ilyas, Asif M, Jones, Christopher M., Kim, Nayoung, Kirkpatrick, William, Leinberry, Charles, Liss, Frederic, Lutsky, Kevin F F., Maltenfort, Mitchell, Matzon, Jonas L., Wang, Mark L.   +10 more
core   +1 more source