Results 131 to 140 of about 697,718 (358)

Analgesic impact of intra‐operative opioids vs. opioid‐free anaesthesia: a systematic review and meta‐analysis

Anaesthesia, 2019
Opioids are administered peri‐operatively for postoperative analgesia, and intra‐operatively to control the sympathetic response to surgical stimuli, frequently as a surrogate for presumed pain.
J. Frauenknecht, K. Kirkham, A. Jacot-Guillarmod, E. Albrecht   +3 more
semanticscholar   +1 more source

Low‐dose cannabidiol increases plasma concentrations of amitriptyline: A clinical drug–drug interaction study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko, Titiaan E. Post, Pamela K. Strugala, Erica S. Klaassen, Linda E. Klumpers, Saco J. de Visser, Cristina Sempio, Jost Klawitter, Jules A. A. C. Heuberger, Geert J. Groeneveld   +9 more
wiley   +1 more source

Unemployment and opioid overdose death patterns in the United States from 2017 to 2019

Interdisciplinary Journal of Epidemiology and Public Health
Introduction: Unemployment has been linked to increased opioid-related harms such as opioid overdose deaths. Identifying hotspots and coldspots across the United States (US) can be crucial to understanding health resources and leveraging strategies ...
Rana Khafagy, Saranya Naraentheraraja, Aranee Sathiyamoorthy   +2 more
doaj   +1 more source

Tourniquetless Total Knee Arthroplasty With Modern Perioperative Protocols Decreases Pain and Opioid Consumption in Women [PDF]

, 2018
Background This study examined whether a modern total knee arthroplasty (TKA) protocol without a tourniquet results in less patient-reported pain and in-hospital opioid consumption compared to TKA with a tourniquet.
Dilley, Julian E., Hood, Mark, Jr., Kheir, Michael M., Meneghini, R. Michael, Ziemba-Davis, Mary   +4 more
core   +1 more source

Association of Lowering Default Pill Counts in Electronic Medical Record Systems With Postoperative Opioid Prescribing [PDF]

, 2018
Alexander S. Chiu, R Jean, Jessica R. Hoag, Mollie Freedman-Weiss, James M. Healy, Kevin Y. Pei   +5 more
openalex   +1 more source

No Shortcuts to Safer Opioid Prescribing.

New England Journal of Medicine, 2019
No Shortcuts to Safer Opioid Prescribing The CDC’s 2016 Guideline for Prescribing Opioids for Chronic Pain has largely been embraced by the medical and health policy communities.
D. Dowell, Tamara M. Haegerich, R. Chou
semanticscholar   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Multimodal analgesia with parasternal plane block protocol within an enhanced recovery after cardiac surgery program decreases opioid useCentral MessagePerspective

JTCVS Open
Objective: This study investigated the efficacy of a multimodal analgesia (MMA) with an opioid-sparing strategy, incorporating a parasternal plane block (PPB) within a systematic standardized Enhanced Recovery After Surgery (ERAS) program for patients ...
Marc Darras, MD, Clément Schneider, MD, Sandrine Marguerite, MD, Saadé Saadé, MD, Anne-Lise Maechel, MD, Walid Oulehri, MD, Olivier Collange, MD, PhD, Jean-Philippe Mazzucotelli, MD, PhD, Paul-Michel Mertes, MD, PhD, Michel Kindo, MD, PhD   +9 more
doaj   +1 more source

Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]

, 2013
There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Ammer, Hermann, Koutnik, Sarah, Weingaertner, Inka Regine   +2 more
core   +2 more sources

Sentience in cephalopod molluscs: an updated assessment

Biological Reviews, EarlyView.
ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell, Heather Browning, Andrew Crump, Charlotte C. Burn, Jonathan Birch   +4 more
wiley   +1 more source