Results 131 to 140 of about 593,453 (414)

Opioid Prescribing in the United States.

The American Journal of Nursing, 2018
Evidence-based information for nurses on the risks and benefits of prescription opioids.
G. Guy, R. Shults
semanticscholar   +1 more source

PRODUCTION OF 11C‐LABELED AMIDES VIA “IN‐LOOP” 11C‐CARBONYLATION

Asian Journal of Organic Chemistry, Accepted Article.
The carbon‐11 (11C) labeling of benzamides holds great promise in the development of PET radiotracers given the prevalence of benzamides in bioactive molecules. This work establishes an improved automated route to carbon‐11 labeled primary benzamides through carbonylative cross‐coupling of aryl halides with carbon‐11 carbon monoxide using electrophilic
Tanpreet Kaur, Xia Shao, Allen F. Brooks, Peter J. H. Scott   +3 more
wiley   +1 more source

Naloxone distribution programs in the emergency department: A scoping review of the literature

Journal of the American College of Emergency Physicians Open
This scoping review summarized the literature regarding naloxone distribution from emergency departments (EDs) without a prescription. Our intention was to examine various naloxone distribution programs, their methodologies, and the level of ...
Mohan K. Sindhwani, Adam Friedman, Maureen O'Donnell, Donald Stader, Scott G. Weiner   +4 more
doaj   +1 more source

A influência da morfina ou tramadol pela via epidural no trânsito gastrintestinal de equinos

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Os opioides são utilizados na medicina veterinária na analgesia dos animais, porém há restrição quanto ao uso desses fármacos em equinos, pois podem desencadear alterações gastrintestinais, mas a administração pela via epidural minimiza os efeitos
C.M. Bertonha, C.A.A. Valadão, M.H. Cruz, M. Takeda, B.F. Cholfe   +4 more
doaj   +1 more source

Chronic Opioid Use After Surgery: Implications for Perioperative Management in the Face of the Opioid Epidemic

Anesthesia and Analgesia, 2017
Physicians, policymakers, and researchers are increasingly focused on finding ways to decrease opioid use and overdose in the United States both of which have sharply increased over the past decade.
Jennifer M. Hah, B. Bateman, J. Ratliff, Catherine Curtin, E. Sun   +4 more
semanticscholar   +1 more source

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

eLife, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Kathryn E Livingston, Jacob P Mahoney, Aashish Manglik, Roger K Sunahara, John R Traynor   +4 more
doaj   +1 more source

Evaluating the impact of a national naloxone programme on ambulance attendance at overdose incidents: a controlled time-series analysis [PDF]

, 2017
Background and Aims: It has been suggested that distributing naloxone to people who inject drugs (PWID) will lead to fewer attendances by emergency medical services at opioid-related overdose incidents if peer administration of naloxone was perceived ...
Ashworth, Becketti, Bennett, Bird, Box, Clark, Craig, Darke, Darke, Davoli, Jarosz, Knowlton, Lankenau, Lenton, Longo, McAuley, McAuley, McCain, Merchant, Merrall, Moore, Salmon, Seal, Shermann, Sporer, Strang, Walley, Weatherburn, World Health Organization (WHO), Wright   +29 more
core   +2 more sources

Modeling the prescription opioid epidemic [PDF]

, 2017
Opioid addiction has become a global epidemic and a national health crisis in recent years, with the number of opioid overdose fatalities steadily increasing since the 1990s. In contrast to the dynamics of a typical illicit drug or disease epidemic, opioid addiction has its roots in legal, prescription medication - a fact which greatly increases the ...
arxiv   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source